Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes
Hua Z, Yang S, Li J, Sun Y, Liao Y, Song S, Cheng S, Li Z, Li Z, Li D, Guo H, Yang H, Zheng Y, Li X
Diabetes, obesity & metabolism · 8 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Beijing Municipal Natural Science Foundation
- Gobierno
- Natural Science Foundation of Beijing Municipality
- Gobierno
- Research and Application of Clinical Characteristic Diagnosis and Treatment Technology in Beijing
- Subvenciones
- Beijing Municipal Natural Science Foundation (Z230021)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-12-01 · Diabetes Obes Metab · vol. 27 · número 2 · págs. 920–932
- Editorial
- Wiley
- Citado
- 10 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, time-restricted eating, 5:2 diet, alternate-day fasting, weight loss, fat mass reduction, insulin, glycemic control, lipid profile, LDL cholesterol, blood pressure, non-alcoholic fatty liver disease, obesity, metabolic health
- MeSH
- humans, obesity, weight loss, treatment outcome, fasting, overweight, intermittent fasting
14 autores
- Zixin Hua🇨🇳Capital Medical University; Beijing Friendship Hospital
- Siyu Yang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Jun Li🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yiqi Sun🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yin Liao🇨🇳Capital Medical University; Beijing Friendship Hospital
- Siyang Song🇨🇳Capital Medical University; Beijing Friendship Hospital
- Sheng Cheng🇨🇳Capital Medical University; Beijing Friendship Hospital
- Zhe Li🇨🇳Capital Medical University; Beijing Friendship Hospital
- LI Ze🇨🇳Capital Medical University; Beijing Friendship Hospital
- Dandan Li🇨🇳Capital Medical University; Beijing Friendship Hospital
- Heng Guo🇨🇳Capital Medical University; Beijing Friendship Hospital
- Hongge Yang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yingming Zheng🇨🇳Capital Medical University; Beijing Friendship Hospital
- Xingang Li🇨🇳 · autor de correspondenciaCapital Medical University; Beijing Friendship Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To provide an updated comprehensive evaluation of the quality and evidence association of existing studies on health outcomes related to intermittent fasting (IF).
Materials and methods
We conducted a systematic search of PubMed, Web of Science, Cochrane Library, and Embase databases, covering literature up to June 2024. Meta-analyses and systematic reviews that include adult populations and quantitatively analyse health outcomes related to IF interventional studies are included. For evidence with complete data, we reanalyzed health evidence effect sizes and 95% confidence intervals using random-effects models. Article quality and the certainty of the evidence were graded using A Measurement Tool to Assess Systematic Reviews (AMSTAR-2), Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, and a standardized credibility grading system.
Results
Twelve meta-analysis studies and 122 health outcome associations with IF were identified. High-quality evidence indicated significant associations between time-restricted eating (TRE) and weight loss, fat mass reduction, decreased fasting insulin and glycosylated haemoglobin levels in overweight or obese adults, as well as between the 5:2 diet and reduced low-density lipoprotein cholesterol levels. Moderate-to-low-quality evidence suggested associations between modified alternate-day fasting and improvements in body weight, lipid profile and blood pressure. Additionally, high-to-low-quality evidence showed that IF regimens effectively improved liver health in non-alcoholic fatty liver disease.
Conclusions
This umbrella review highlights IF, especially TRE, as a promising intervention for weight and metabolic health, particularly beneficial for overweight or obese adults. We also highlight the need for further extensive research to understand the long-term effects, individualized IF plans and potential adverse effects of IF in different populations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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