Changes in choroidal thickness in pre-myopic children after repeated low-level red-light therapy and their role in predicting myopia prevention and controlling myopic shift
Xiang K, Wang J, Zhu Z, Zhang X, Zhang B, Chen J, Yang J, Du L, Ai Z, He X, Xu X
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) · 10 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-12-01 · Asia Pac J Ophthalmol (Phila) · vol. 14 · número 2 · pág. 100115
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 19 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Retinopathy of Prematurity Studies
- Palabras clave
- Ophthalmology, Medicine, Optometry
- MeSH
- choroid, humans, myopia, tomography, optical coherence, refraction, ocular, phototherapy, follow-up studies, visual acuity, child, female, male
11 autores
- Kaidi Xiang🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Jingjing Wang🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Zhuoting Zhu🇦🇺The University of Melbourne; Centre for Eye Research Australia
- Xinzi Zhang🇨🇳Shanghai Eye Disease Prevention & Treatment Center; Shanghai Clinical Research Center
- Bo Zhang🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Jun Chen🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Jinliuxing Yang🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Linlin Du🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Zhiyong Ai🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Xiangui He🇨🇳Shanghai Eye Disease Prevention & Treatment Center
- Xun Xu🇨🇳Shanghai Eye Disease Prevention & Treatment Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To investigate longitudinal changes in choroidal thickness (ChT) after 1-year treatment of repeated low-level red-light (RLRL) and their predictive value in efficacy on myopia prevention and myopic shift among pre-myopic children.
Methods
278 pre-myopic (-0.50 D < spherical equivalent refraction, SER ≤ 0.50 D) participants were assigned to the RLRL group and control group randomly and evenly. The OCT, visual acuity, AL, SER and other parameters were measured before enrollment and every 3 months after intervention. The data from both eyes of the included participants were analyzed.
Results
A total of 463 eyes were analyzed. Due to the COVID-19 pandemic, 176 participants in the RLRL group had treatment interrupted. The continued RLRL group, interrupted RLRL group and control group were well balanced in baseline characteristics. In the continued and interrupted RLRL group, the average ChT increased significantly at 3-month visit (all P < 0.001) and the subfoveal ChT thickened evidently. The area under the curve (AUC) for the models including gender and 3-month change in ChT to predict satisfactory myopia prevention at 12 months was 0.983. The efficacy of the models that also used the combined indicators of baseline age, gender and the 3-month change in ChT to predict AL progression control over 12 months reached 0.944.
Conclusions
Continued RLRL intervention induced notable thickening of ChT in premyopic population, especially at the subfoveal sector. For participants received RLRL treatment, the 3-month change in ChT combined with other baseline factors have acceptable predictive discrimination of myopia prevention efficacy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.