Increased magnesium intake does not mitigate MAFLD risk associated with magnesium deficiency
Peng H, Zhao M, Zhang Y, Guo Y, Zhao A
Scientific reports · 3 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Chongqing
- Universidad u hospital
- Centre Scientifique et Technique du Bâtiment
- Gobierno
- Special Funding for Postdoctoral Research Project of Chongqing
- Gobierno
- Natural Science Foundation of Chongqing, China
- Gobierno
- National Nature Science Foundation of China
- Subvenciones
- Natural Science Foundation of Chongqing (CSTB2022NSCQ); National Natural Science Foundation of China (82102337)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-12-05 · Sci Rep · vol. 14 · número 1 · pág. 30386
- Editorial
- Nature Portfolio
- Citado
- 5 citas · más que el 75% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Nutrition and Health in Aging
- Palabras clave
- Magnesium deficiency (plants), Magnesium, Medicine, Internal medicine, Endocrinology, Chemistry
- MeSH
- humans, fatty liver, magnesium deficiency, magnesium, risk factors, oxidative stress, adult, aged, middle aged, united states, female, male
5 autores
- Haiyang Peng🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Minjie Zhao🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Yuezhou Zhang🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Yaoyuan Guo🇨🇳Chongqing Medical and Pharmaceutical College
- Andong Zhao🇨🇳 · autor de correspondenciaDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Serum magnesium cannot accurately assess magnesium deficiency. The association between magnesium deficiency and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. Selecting 3,377 participants in the United States, we assessed the degree of magnesium deficiency in the population using magnesium depletion score (MDS). Multinomial logistic regression assessed the association between magnesium deficiency and MAFLD. Subgroup analyses assessed the association between dietary magnesium intake and MAFLD under different magnesium deficiency statuses. Structural equation modeling (SEM) revealed mediation effects. Magnesium deficiency was associated with MAFLD (ORseverevs.none: 1.69, 95%CI: 1.16-2.46; p for trend < 0.001). Magnesium intake was negatively associated with MAFLD only in the subgroup without magnesium deficiency (p for trend < 0.01). Inflammation, oxidative stress, and aging significantly mediated the association between MDS and MAFLD (all p < 0.05). In American adults, magnesium deficiency assessed by MDS might be a risk factor for MAFLD, with inflammation, oxidative stress, and aging potentially being key mechanisms. Simply increasing magnesium intake would not mitigate MAFLD risk associated with magnesium deficiency. Correcting magnesium deficiency might prevent MAFLD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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