Mild hypohydration in healthy older adults increases pain-related brain activity without affecting pain perception: a single-blind study
Deshayes TA, Savoie FA, Pancrate T, Jolicoeur Desroches A, Morais JA, Bernier PM, Léonard G, Simoneau IL, Goulet EDB
Journal of applied physiology (Bethesda, Md. : 1985) · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Centre de recherche sur le vieillissement
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-12-10 · J Appl Physiol (1985) · vol. 138 · número 1 · págs. 238–249
- Editorial
- American Physiological Society
- Citado
- 1 cita · más que el 57% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Thermoregulation and physiological responses · Pain Management and Placebo Effect · Acupuncture Treatment Research Studies
- Palabras clave
- Anesthesia, Hypertonic saline, Nociception, Medicine, Thirst, Electroencephalography, Population, Noxious stimulus, Dehydration, Ingestion, Internal medicine, Chemistry
- MeSH
- brain, humans, pain, dehydration, electroencephalography, single-blind method, evoked potentials, osmolar concentration, aged, female, male, pain perception
9 autores
- Thomas A. Deshayes🇨🇦Université de Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
- Félix-Antoine Savoie🇨🇦Université du Québec à Rimouski; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
- Timothée Pancrate🇨🇦Université de Sherbrooke
- Antoine Jolicoeur Desroches🇨🇦Université de Sherbrooke
- José A. Morais🇨🇦McGill University Health Centre; McGill University
- Pierre‐Michel Bernier🇨🇦Université de Sherbrooke
- Guillaume Léonard🇨🇦Université de Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
- Ivan L. Simoneau🇨🇦Cégep de Sherbrooke
- Eric D. B. Goulet🇨🇦Université de Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Understanding how hydration status influences pain perception is particularly important in older adults, as both dehydration and pain are prevalent in this population. Ten individuals (70 ± 4 yr) completed two randomized and counterbalanced trials. They were exposed to passive heat until they lost 1% body mass through sweat and urine (∼100 min), with the loss either unreplaced (sham infusion, HYPO) or fully replaced via 0.45% saline infusion (EUH). Nociceptive electrical stimulation was applied to the sural nerve 1) before heat exposure (baseline), 2) 60 min following hydration manipulation (R60, ∼160 min after baseline), 3) after mouth rinsing with water (MR, ∼170 min after baseline), and 4) following water ingestion (ING, ∼185 min after baseline). Pain-related event-related potentials were assessed using electroencephalography (EEG) at R60, MR, and ING. After hydration manipulation, body mass loss and plasma osmolality were greater, and plasma volumes were lower in HYPO than in EUH, although thirst did not differ between the conditions. There were no differences between the two conditions regarding pain intensity and unpleasantness. Still, EEG analyses revealed that the peak-to-peak amplitude of the pain-related N200-P300 potential (∼136-310 ms) was significantly greater in HYPO than in EUH (P = 0.036) and significantly greater in R60 compared with both MR (P = 0.01) and ING (P = 0.03), either with HYPO and EUH. These results suggest that mild hypohydration in healthy older adults may influence some neurophysiological processes related to nociception without significantly affecting pain perception.NEW & NOTEWORTHY This study reveals, for the first time, that mild hypohydration equivalent to ∼1% of body mass does not alter pain perception in healthy older adults when they are blinded to their hydration status, despite electroencephalography signals showing modulation of pain-related brain responses.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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