Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration
Chen H, Liu C, Cui S, Xia Y, Zhang K, Cheng H, Peng J, Yu X, Li L, Yu H, Zhang J, Zheng JS, Zhang B
Cell · 26 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Westlake University
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (32170850)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-12-13 · Cell · vol. 188 · número 1 · págs. 157–174.e22
- Editorial
- Cell Press
- Citado
- 39 citas · más que el 99% de estudios similares · 16.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 86 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Hair Growth and Disorders · Dietary Effects on Health · Reproductive Biology and Fertility
- Palabras clave
- intermittent fasting, hair follicle regeneration, hair follicle stem cells, apoptosis, inter-organ communication, adrenal gland, free fatty acids, reactive oxygen species, oxidative stress, stem cell niche, tissue regeneration, hair growth
- MeSH
- hair follicle, adipocytes, stem cells, animals, humans, mice, reactive oxygen species, fasting, regeneration, apoptosis, adult, female, male, mechanistic target of rapamycin complex 1, intermittent fasting
13 autores
- Han Chen🇨🇳Westlake University; Zhejiang University
- Chao Liu🇨🇳Westlake University
- Shiyao Cui🇨🇳Westlake University
- Yingqian Xia🇨🇳Westlake University
- Ke Zhang🇨🇳Westlake University
- Hanxiao Cheng🇨🇳Westlake University; Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine
- Jingyu Peng🇨🇳Westlake University
- Xiaoling Yu🇨🇳Westlake University
- Luyang Li🇨🇳Westlake University
- Hualin Yu🇨🇳Westlake University; Zhejiang University
- Jufang Zhang🇨🇳Westlake University; Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine
- Ju‐Sheng Zheng🇨🇳Westlake University
- Bing Zhang🇨🇳 · autor de correspondenciaWestlake University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting has gained global popularity for its potential health benefits, although its impact on somatic stem cells and tissue biology remains elusive. Here, we report that commonly used intermittent fasting regimens inhibit hair follicle regeneration by selectively inducing apoptosis in activated hair follicle stem cells (HFSCs). This effect is independent of calorie reduction, circadian rhythm alterations, or the mTORC1 cellular nutrient-sensing mechanism. Instead, fasting activates crosstalk between adrenal glands and dermal adipocytes in the skin, triggering the rapid release of free fatty acids into the niche, which in turn disrupts the normal metabolism of HFSCs and elevates their cellular reactive oxygen species levels, causing oxidative damage and apoptosis. A randomized clinical trial (NCT05800730) indicates that intermittent fasting inhibits human hair growth. Our study uncovers an inhibitory effect of intermittent fasting on tissue regeneration and identifies interorgan communication that eliminates activated HFSCs and halts tissue regeneration during periods of unstable nutrient supply.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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