Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial
Souza JT, Minicucci MF, Ferreira NC, Polegato BF, Okoshi MP, Modolo GP, Leal-Pereira FW, Phillips BE, Atherton PJ, Smith K, Wilkinson DJ, Gordon AL, Tanni SE, Costa VE, Fernandes MF, Bazan SG, Zornoff LM, Paiva SR, Bazan R, Azevedo PS
Nutrients · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidad u hospital
- NIHR Nottingham Biomedical Research Centre
- Gobierno
- National Council for Scientific and Technological Development (CNPq)
- Gobierno
- CAPES—001–Notice 02
- Gobierno
- Coordination for the Improvement of Higher Education Personnel (CAPES)—001
- Sin clasificar
- Voucher for Special Issue
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (310398/2018-5); Conselho Nacional de Desenvolvimento Científico e Tecnológico (435047/2018-3)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-11-29 · Nutrients · vol. 16 · número 23 · pág. 4148
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 7 citas · más que el 79% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Clinical Nutrition and Gastroenterology
- Palabras clave
- creatine supplementation, stroke, muscle mass, muscle strength, functional capacity, older adults, acute stroke, progranulin, inflammation, muscle degradation, protein supplementation, mobility training, quality of life, mortality
- MeSH
- muscle, skeletal, humans, creatine, treatment outcome, double-blind method, quality of life, dietary supplements, aged, aged, 80 and over, female, male, muscle strength, stroke, biomarkers, stroke rehabilitation
20 autores
- Juli Thomaz de Souza🇧🇷 · autor de correspondenciaUniversidade Estadual Paulista (Unesp)
- Marcos Ferreira Minicucci🇧🇷Universidade Estadual Paulista (Unesp)
- Natália Cristina Ferreira🇧🇷Universidade Estadual Paulista (Unesp)
- Bertha Furlan Polegato🇧🇷Universidade Estadual Paulista (Unesp)
- Marina Politi Okoshi🇧🇷Universidade Estadual Paulista (Unesp)
- Gabriel Pinheiro Módolo🇧🇷Universidade Estadual Paulista (Unesp)
- Filipe W. Leal-Pereira🇧🇷Universidade Estadual Paulista (Unesp)
- Bethan Eileen Phillips🇬🇧University of Nottingham; National Institute for Health and Care Research; Arthritis UK; Nottingham Biomedical Research Centre
- Philip James Atherton🇬🇧University of Nottingham; National Institute for Health and Care Research; Arthritis UK; Nottingham Biomedical Research Centre
- Kenneth Smith🇬🇧University of Nottingham; National Institute for Health and Care Research; Arthritis UK; Nottingham Biomedical Research Centre
- Daniel James Wilkinson🇬🇧University of Nottingham; National Institute for Health and Care Research; Arthritis UK; Nottingham Biomedical Research Centre
- Adam Lee Gordon🇬🇧Queen Mary University of London; Barts Health NHS Trust; Whipps Cross University Hospital
- Suzana Érico Tanni🇧🇷Universidade Estadual Paulista (Unesp)
- Vladimir Eliodoro Costa🇧🇷Universidade Estadual Paulista (Unesp)
- Maria F. Fernandes🇧🇷Universidade Estadual Paulista (Unesp)
- Silméia Garcia Zanati Bazan🇧🇷Universidade Estadual Paulista (Unesp)
- Leonardo Antônio Mamede Zornoff🇧🇷Universidade Estadual Paulista (Unesp)
- Sérgio Alberto Rupp de Paiva🇧🇷Universidade Estadual Paulista (Unesp)
- Rodrigo Bazán🇧🇷Universidade Estadual Paulista (Unesp)
- Paula S. Azevedo🇧🇷Universidade Estadual Paulista (Unesp)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
The acute phase of stroke is marked by inflammation and mobility changes that can compromise nutritional status. This study was a randomized, double-blind, placebo-controlled trial evaluating the effectiveness of creatine supplementation for older people during seven days of hospitalization for stroke compared to usual care.
Method
The primary outcome measures were changes in functional capacity, strength, muscle mass, and muscle degradation. The secondary outcomes were changes in serum biomarkers related to inflammation, fibrosis, anabolism, and muscle synthesis. In addition, a follow-up 90 days after the stroke verified functional capacity, strength, quality of life, and mortality. Following admission for an acute stroke, participants received either creatine (10 g) or a visually identical placebo (10 g) orally twice daily. Both groups received supplementation with protein to achieve the goal of 1.5 g of protein/kg of body weight/day and underwent daily mobility training during seven days of hospitalization.
Results
Thirty older people were included in two similar groups concerning baseline attributes (15-treatment/15-placebo).
Conclusions
Creatine supplementation did not influence functional capacity, strength, or muscle mass during the first 7 days or outcomes 90 days after stroke. There were no serious adverse events associated with creatine supplementation. However, it decreased progranulin levels, raising a new possibility of creatine action. This finding needs further exploration to understand the biological significance of creatine-progranulin interaction.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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