Is isocaloric intermittent fasting superior to calorie restriction? A systematic review and meta-analysis of RCTs
Hamsho M, Shkorfu W, Ranneh Y, Fadel A
Nutrition, metabolism, and cardiovascular diseases : NMCD · 7 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- United Arab Emirates University
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-11-23 · Nutr Metab Cardiovasc Dis · vol. 35 · número 3 · pág. 103805
- Editorial
- Elsevier BV
- Citado
- 13 citas · más que el 73% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Palabras clave
- intermittent fasting, caloric restriction, weight loss, fat mass, waist circumference, insulin resistance, HOMA-IR, interleukin-6, inflammatory markers, adipokines, hunger, fatigue, triglycerides, dietary adherence, intervention duration, older adults
- MeSH
- humans, obesity, weight loss, blood glucose, inflammation mediators, treatment outcome, caloric restriction, fasting, time factors, adult, aged, middle aged, female, male, adiposity, randomized controlled trials as topic, adipokines, biomarkers, intermittent fasting
4 autores
- Mohammed Hamsho🇹🇷Istanbul Yeni Yüzyıl University
- Wijdan Shkorfu🇹🇷Bahçeşehir University
- Yazan Ranneh🇦🇪Al Ain University
- Abdulmannan Fadel🇦🇪United Arab Emirates University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
Intermittent fasting (IF) has been demonstrated to enhance human health through several mechanisms. However, it is still unclear whether those health benefits are independent of caloric restriction (CR)-induced weight loss. This systematic review and meta-analysis aimed to compare isocaloric IF and CR regarding anthropometric measurements, adherence, metabolic profile, inflammatory biomarkers, and adipokines in adults and elderlies.
Methods and results
Comprehensive research was conducted usin four major databases including Embase, PubMed, Scopus, and Google Scholar without date restriction. Mean differences of the change from baseline ± change SD were calculated as the differences between IF and CR groups. Subgroup analysis was performed according to intervention duration (short-, medium-, and long-term). To determine the reliability of our findings, GRADE assessment was performed. As a result, 20 RCTs were included in this systematic review and meta-analysis. IF groups had significant reductions in fat mass (kg) (P = 0.006) and Interleukin-6 (P < 0.00001) in the short term and fat mass (%) (P = 0.0002), waist circumference (P = 0.005), fasting blood insulin (P < 0.00001) and HOMA-IR (P = 0.04) in the long term. CR groups had significantly lower hunger (P = 0.003), fatigue (P = 0.04), and TG (P = 0.03).
Conclusions
IF may be an effective alternative to CR but is not superior to CR in enhancing human health. Due to the low number of long-term studies, future studies should focus on conducting longitudinal randomized trials comparing IF and CR in different populations, age groups, and IF patterns.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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