Financiado en parte por American Pistachio Growers
Effect of Premeal Pistachio Supplementation on Cardiometabolic Risk Factors among Asian Indian Adults with Prediabetes: A Randomized Controlled Trial
Ashwini K, Abirami K, Gayathri R, Sasikala S, Sudha V, Shobana S, Jeevan RG, Krishnaswamy K, Deepika V, Rajalakshmi M, Bai R MR, Parkavi K, Padmavathi S, Anjana RM, Unnikrishnan R, Hu FB, Willett WC, Salas-Salvadó J, Bhupathiraju SN, Mohan V
The Journal of nutrition · 1 cita
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- American Pistachio Growers
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-01-31 · J Nutr · vol. 155 · número 3 · págs. 899–909
- Editorial
- Elsevier BV
- Citado
- 7 citas · más que el 92% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- prediabetes, Asian Indians, cardiometabolic risk factors, HbA1c, glycemic control, lipid profile, visceral fat, continuous glucose monitoring, nuts, type 2 diabetes prevention, dietary intervention, glycemic load, atherogenic index, lipid accumulation product, waist circumference
- MeSH
- humans, pistacia, nuts, prediabetic state, blood glucose, dietary supplements, adult, middle aged, india, female, male, cardiometabolic risk factors, glycated hemoglobin, south asian people
20 autores
- Karthikeyan Ashwini🇮🇳University of Madras; Madras Diabetes Research Foundation
- Kuzhandhaivelu Abirami🇮🇳Madras Diabetes Research Foundation
- R. Gayathri🇮🇳Madras Diabetes Research Foundation
- Sekar Sasikala🇮🇳Madras Diabetes Research Foundation
- Vasudevan Sudha🇮🇳Madras Diabetes Research Foundation
- Shanmugam Shobana🇮🇳University of Madras; Madras Diabetes Research Foundation
- Raman Ganesh Jeevan🇮🇳Madras Diabetes Research Foundation
- Kamala Krishnaswamy🇮🇳Madras Diabetes Research Foundation
- Vadivelu Deepika🇮🇳Madras Diabetes Research Foundation
- Marimuthu Rajalakshmi🇮🇳Madras Diabetes Research Foundation
- Mookambika Ramya Bai R🇮🇳Madras Diabetes Research Foundation
- Karthikeyan Parkavi🇮🇳Madras Diabetes Research Foundation
- Soundararajan Padmavathi🇮🇳Madras Diabetes Research Foundation
- Ranjit Mohan Anjana🇮🇳Madras Diabetes Research Foundation; Dr. Mohan's Diabetes Specialities Centre
- Ranjit Unnikrishnan I🇮🇳Madras Diabetes Research Foundation; Dr. Mohan's Diabetes Specialities Centre
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Walter Churchill Willett🇺🇸Harvard University
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Viswanathan Mohan🇮🇳 · autor de correspondenciaMadras Diabetes Research Foundation; Dr. Mohan's Diabetes Specialities Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Asian Indians are susceptible to developing type 2 diabetes at a lower age and often consume diets that are high in glycemic load and low in healthy fats.
Objectives
This study aimed to evaluate the effect of 30 g prebreakfast and 30 g predinner supplementation of pistachios for 12 wk on glycated hemoglobin (HbA1c), other glycemic markers, anthropometry, and lipid profile of Asian Indians with prediabetes.
Methods
In a 12-wk parallel arm, randomized controlled trial, we recruited 120 participants with prediabetes based on American Diabetes Association criteria. The intervention group (n = 60) consumed 60 g pistachios (30 g prebreakfast and predinner) whereas the control group (n = 60) followed a routine diet that excluded nuts. At baseline and 12 wk, we collected blood samples for biochemical analysis, anthropometrics, and 24-h recalls. Participants wore a continuous glucose monitoring (CGM) sensor during the trial's first and last 2 wk. Urinary N-methyl-trans-4-hydroxy-l-proline (MHP) was measured as a marker of pistachio consumption.
Results
A total of 109 participants completed the study (follow-up rate = 90.8%). Compared with participants in the control group, those in the intervention group had significant reductions in HbA1c (mean between-group difference: -0.2; 95% confidence interval: -0.3, -0.1; P < 0.001] with no significant changes in fasting or 2-h post glucose load plasma glucose. Compared with the control group, the intervention group had significant reductions in serum triglyceride, waist circumference, lipid accumulation product, visceral adiposity index, and atherogenic index. Urinary MHP (mg/g creatinine) showed a 62% increase in the intervention compared with the control group (P < 0.05). CGM data revealed significant decreases in the incremental area under the curve, 2-h after breakfast (28%, p=0.01) and after dinner (17%, P = 0.002) in the intervention group compared to the control group.
Conclusions
A 12-wk, premeal load of 60 g pistachios lowers HbA1c and improves cardiometabolic profile among Asian Indians with prediabetes. This is among the first studies to investigate these effects in this ethnic group. This study was registered in the Clinical Trial Registry of India as CTRI/2020/11/029340.
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