A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
Llauradó-Pont J, Stratakis N, Fiorito G, Handakas E, Neumann A, Barros H, Brantsæter AL, Chang K, Chatzi L, Felix JF, Grazuleviciene R, Jaddoe VWV, Karachaliou M, Lecorguillé M, Lopes C, Millett C, McEachan RRC, Papadopoulou E, Slama R, Vamos EP, Vineis P, Vrijheid M, Wright J, Voortman T, Bustamante M, Robinson O, Lassale C
Clinical epigenetics · 10 citas
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- HORIZON EUROPE Marie Sklodowska-Curie Actions (101059245); European Commission (874739); European Commission (2022 INV-1 00046); European Commission (2007–2013); Agencia Estatal de Investigación (13039); European Commission (FP7 2007-2013); ZonMw (529051023); European Commission (HORIZON2020); European Commission (874583); H2020 Marie Skłodowska-Curie Actions (FP7/2007-2013); European Commission (FP7/2007); Agencia Estatal de Investigación (00110); European Commission (308333); Medical Research Council (MC_PC_15018); HORIZON EUROPE Framework Programme (874583); HORIZON EUROPE European Research Council (101039672); H2020 Marie Skłodowska-Curie Actions (HORIZON2020); Medical Research Council (MR/M501669/1); Medical Research Council (MC_PC_19009); ZonMw (529051022)
Según 25 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-01-07 · Clin Epigenetics · vol. 17 · número 1 · pág. 3
- Editorial
- BioMed Central
- Citado
- 15 citas · más que el 83% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 104 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Epigenetics and DNA Methylation · Consumer Attitudes and Food Labeling · Birth, Development, and Health
- Palabras clave
- ultra-processed foods, DNA methylation, children, NOVA classification, CpG sites, ATF7, thyroid hormones, liver function, blood DNA methylation
- MeSH
- humans, diet, dna methylation, epigenesis, genetic, cpg islands, child, child, preschool, europe, female, male, genome-wide association study, fast foods, epigenome, food, processed
27 autores
- Joana Llauradó-Pont🇪🇸Barcelona Institute for Global Health
- Nikos Stratakis🇪🇸Barcelona Institute for Global Health
- Giovanni Fiorito🇮🇹Istituto Giannina Gaslini
- Evangelos Handakas🇬🇧MRC Centre for Environment and Health; Imperial College London
- Alexander Neumann🇳🇱Erasmus MC
- Henrique Barros🇵🇹Universidade do Porto; Institute of Public Health, University of Porto
- Anne Lise Brantsæter🇳🇴Norwegian Institute of Public Health
- Kiara Chang🇬🇧Imperial College London
- Leda Chatzi🇺🇸University of Southern California
- Janine F. Felix🇳🇱Erasmus MC
- Regina Gražulevičienė🇱🇹Vytautas Magnus University
- Vincent W. V. Jaddoe🇳🇱Erasmus MC
- Marianna Karachaliou🇪🇸Barcelona Institute for Global Health
- Marion Lecorguillé🇫🇷Inserm; Université Paris Cité; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université Sorbonne Paris Nord; Centre de Recherche Épidémiologie et Statistique
- Carla Maria Moura Lopes🇵🇹Universidade do Porto; Institute of Public Health, University of Porto
- Christopher J. Millett🇵🇹🇬🇧Comprehensive Health Research Centre; Imperial College London; Universidade Nova de Lisboa
- Rosemary McEachan🇬🇧Bradford Teaching Hospitals NHS Foundation Trust; Bradford Institute for Health Research
- Eleni Papadopoulou🇳🇴Norwegian Institute of Public Health
- Rémy Slama🇫🇷Centre National de la Recherche Scientifique; Inserm; Institut pour l'avancée des biosciences; Université Grenoble Alpes
- Eszter Panna Vamos🇬🇧Imperial College London
- Paolo Vineis🇬🇧MRC Centre for Environment and Health; Imperial College London
- Martine Vrijheid🇪🇸Universitat Pompeu Fabra; Instituto de Salud Carlos III; Barcelona Institute for Global Health; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- John Wright🇬🇧Bradford Teaching Hospitals NHS Foundation Trust; Bradford Institute for Health Research
- Trudy Voortman🇳🇱Erasmus MC
- Mariona Bustamante🇪🇸Universitat Pompeu Fabra; Instituto de Salud Carlos III; Barcelona Institute for Global Health; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Oliver Robinson🇬🇧MRC Centre for Environment and Health; Imperial College London
- Camille M. Lassale🇪🇸 · autor de correspondenciaUniversitat Pompeu Fabra; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Barcelona Institute for Global Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objective
There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emerging as an important factor impacting health, but mechanisms need to be uncovered. We therefore aimed to assess the association between UPF consumption and DNA methylation in children.
Methods
We conducted a meta-analysis of epigenome-wide association studies (EWAS) from a total of 3152 children aged 5-11 years from four European studies (HELIX, Generation XXI, ALSPAC, and Generation R). UPF consumption was defined applying the Nova food classification system (group 4), and DNA methylation was measured in blood with Illumina Infinium Methylation arrays. Associations were estimated within each cohort using robust linear regression models, adjusting for relevant covariates, followed by a meta-analysis of the resulting EWAS estimates.
Results
Although no CpG was significant at FDR level, we found suggestive associations (p-value -5) between UPF consumption and methylation at seven CpG sites. Three of them, cg00339913 (PHYHIP), cg03041696 (intergenic), and cg03999434 (intergenic), were negatively associated, whereas the other four, cg14665028 (NHEJ1), cg18968409 (intergenic), cg24730307 (intergenic), and cg09709951 (ATF7), were positively associated with UPF intake. These CpGs have been previously associated with health outcomes such as carcinomas, and the related genes are mainly involved in pathways related to thyroid hormones and liver function.
Conclusion
We only found suggestive changes in methylation at 7 CpGs associated with UPF intake in a large EWAS among children: although this shows a potential impact of UPF intake on DNAm, this might not be a key mechanism underlying the health effects of UPFs in children. There is a need for more detailed dietary assessment in children studies and of intervention studies to assess potential epigenetic changes linked to a reduction in UPF in the diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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