The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial
Tavakoli A, Akhgarjand C, Ansar H, Houjaghani H, Khormani A, Djafarian K, Rostamian A, Ranjbar M, Farsani GM
Scientific reports · 14 citas
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- Financiación independiente
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Publicación
- Publicado
- 2025-01-18 · Sci Rep · vol. 15 · número 1 · pág. 2357
- Editorial
- Nature Portfolio
- Citado
- 21 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Rheumatoid Arthritis Research and Therapies · Exercise and Physiological Responses
- Palabras clave
- intermittent fasting, 16:8 fasting, rheumatoid arthritis, postmenopausal women, obesity, overweight, oxidative stress, inflammatory markers, malondialdehyde, catalase, neutrophil-to-lymphocyte ratio, liver enzymes, aspartate aminotransferase, alanine aminotransferase, non-pharmacological treatment
- MeSH
- liver, humans, arthritis, rheumatoid, obesity, inflammation, malondialdehyde, alanine transaminase, aspartate aminotransferases, antioxidants, fasting, oxidative stress, postmenopause, aged, middle aged, female, overweight, biomarkers, intermittent fasting
9 autores
- Aryan Tavakoli🇮🇷Tehran University of Medical Sciences
- Camellia Akhgarjand🇮🇷Tehran University of Medical Sciences
- Hastimansooreh Ansar🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- Hirad Houjaghani🇮🇷Iran University of Medical Sciences
- Amirhossein Khormani🇮🇷Shariati Hospital; Tehran University of Medical Sciences
- Kurosh Djafarian🇮🇷Tehran University of Medical Sciences
- Abdolrahman Rostamian🇮🇷Rheumatology Research Center; Tehran University of Medical Sciences
- Mahsa Ranjbar🇮🇷Tehran University of Medical Sciences
- Gholamreza Mohammadi Farsani🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting postmenopausal women. This study investigated the effects of intermittent fasting (IF) on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with RA. This 8-week randomized controlled trial included 44 postmenopausal women with RA divided into an intervention group following a 16:8 IF diet and a control group maintaining their usual diet and received recommendations for healthy eating. Inflammatory indices, oxidative stress markers, and liver enzymes were measured at baseline and post intervention. The IF group showed significant decreases in serum malondialdehyde (MDA) levels (P = 0.02) and neutrophil-to-lymphocyte ratio (P = 0.018) and increased catalase levels (P = 0.004) compared to the control group. Liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) also decreased significantly in the IF group (P = 0.02 and P = 0.03, respectively). No significant differences were observed in the other measured parameters between groups. In conclusion, the 16:8 IF diet demonstrated beneficial effects on some oxidative stress markers, inflammatory indices, and liver enzymes in postmenopausal, overweight, and obese women with RA. These findings suggest that IF may be an effective non-pharmacological intervention for managing RA in this population, potentially addressing both primary disease symptoms and associated metabolic complications. Further research is needed to elucidate the long-term effects and mechanisms of IF in the management of RA.
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