Effects of Ramadan intermittent fasting on hormones regulating appetite in healthy individuals: A systematic review and meta-analysis
Alogaiel DM, Alsuwaylihi A, Alotaibi MS, Macdonald IA, Lobo DN
Clinical nutrition (Edinburgh, Scotland) · 4 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- Arthritis Research UK
- Gobierno
- Ministry of Education – Kingdom of Saudi Arabi
- Organización sin fines de lucro
- Versus Arthritis
- Gobierno
- Medical Research Council
- Universidad u hospital
- NIHR Nottingham Biomedical Research Centre
- Gobierno
- Kingdom of Saudi Arabia Ministry of Education
- Gobierno
- UK Research and Innovation Medical Research Council
- Subvenciones
- National Institute for Health and Care Research (NIHR203310); Medical Research Council (MR/K00414X); Medical Research Council (19891); Medical Research Council (K00414X); NIHR Nottingham Biomedical Research Centre (NIHR203310); Medical Research Council (MR/K00414X/1); Medical Research Council (MR/K00414X/1)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2025-01-06 · Clin Nutr · vol. 45 · págs. 250–261
- Editorial
- Elsevier BV
- Citado
- 9 citas · más que el 80% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 92 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Regulation of Appetite and Obesity · Eating Disorders and Behaviors
- Palabras clave
- appetite-regulating hormones, ghrelin, leptin, insulin, gastrin, glucagon-like peptide-1, peptide YY, cholecystokinin, fasting
- MeSH
- humans, cholecystokinin, peptide yy, insulin, leptin, fasting, appetite, appetite regulation, islam, adult, female, male, glucagon-like peptide 1, ghrelin, healthy volunteers, intermittent fasting
5 autores
- Deema M Alogaiel🇸🇦🇬🇧Princess Nourah bint Abdulrahman University; Nottingham University Hospitals NHS Trust; University of Nottingham; National Institute for Health and Care Research; Queen's Medical Centre; Nottingham Biomedical Research Centre
- Abdulaziz Alsuwaylihi🇬🇧🇸🇦Nottingham University Hospitals NHS Trust; University of Nottingham; King Saud Medical City; National Institute for Health and Care Research; Ministry of Health; Queen's Medical Centre; Nottingham Biomedical Research Centre
- May S. Alotaibi🇸🇦🇬🇧Princess Nourah bint Abdulrahman University; University of Nottingham
- Ian Andrew Macdonald🇬🇧Nottingham University Hospitals NHS Trust; University of Nottingham; National Institute for Health and Care Research; Queen's Medical Centre; Nottingham Biomedical Research Centre
- Dileep N. Lobo🇬🇧🇺🇸Nottingham University Hospitals NHS Trust; University of Nottingham; National Institute for Health and Care Research; Queen's Medical Centre; Nottingham Biomedical Research Centre; University of Pennsylvania
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
This systematic review and meta-analysis aimed to examine the effect of Ramadan intermittent fasting on appetite-regulating hormones including leptin, ghrelin, insulin, gastrin, glucagon-like peptide-1, peptide YY, and cholecystokinin.
Methods
We searched the MEDLINE, Embase, Cochrane Library, CINAHL, Google Scholar, and Web of Science databases to identify relevant research on appetite-regulating hormones during Ramadan intermittent fasting, published until the end of March 2024.
Results
Data from 16 eligible studies comprising 664 participants (341, 51.4 % male) with a mean ± standard deviation age of 33.9 ± 10.8 years were included. The meta-analysis included 12 studies with complete leptin data, showing no significant effect of Ramadan intermittent fasting on leptin concentrations (standardised mean difference - SMD = -0.11 μg/mL, 95 % CI: -0.36 to 0.14). Analysis of three studies with complete ghrelin data demonstrated a significant increase in ghrelin concentrations following Ramadan intermittent fasting (SMD = 0.31 pg/mL, 95 % CI: 0.03 to 0.60). Six studies examining insulin concentrations pre- and post-fasting revealed no significant effect on insulin concentrations (SMD = -0.24 μU/mL, 95 % CI: -0.54 to 0.02). Similarly, analysis of three studies with complete gastrin data showed no significant effect of intermittent fasting on gastrin concentrations (SMD = 0.23 pg/mL, 95 % CI: -0.71 to 0.99).
Conclusion
Ramadan intermittent fasting significantly increases ghrelin concentrations while showing no significant effects on leptin, insulin, and gastrin. While ghrelin findings were consistent across studies, the high heterogeneity in leptin studies suggests further research to better understand the effects of Ramadan intermittent fasting on appetite-regulating hormones.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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