Longer recreational screen time contributes to the risk of age-related macular degeneration: a UK Biobank cohort study and two-sample Mendelian randomisation
Huang Y, Zhang X, Liang L, Jiang Y, Li B, Zhu X, Li C, Gu C, Zou W, Zheng Z, Zhao S
Journal of global health · 1 cita
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (82271111)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-01-30 · J Glob Health · vol. 15 · pág. 04029
- Editorial
- Edinburgh University Global Health Society
- Citado
- 2 citas · más que el 77% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Retinal Diseases and Treatments · Retinal Imaging and Analysis · Ergonomics and Musculoskeletal Disorders
- Palabras clave
- recreational screen time, age-related macular degeneration, retinal thickness, retinal thinning, macular thickness, dose-response relationship, causal relationship, screen time reduction, AMD prevention, optical coherence tomography, UK Biobank, Mendelian randomization, retinal pigment epithelium
- MeSH
- humans, macular degeneration, tomography, optical coherence, proportional hazards models, risk factors, prospective studies, cross-sectional studies, aged, middle aged, biological specimen banks, female, male, genome-wide association study, mendelian randomization analysis, united kingdom, screen time, uk biobank
11 autores
- Yikeng Huang🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Xinyu Zhang🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Liang Li🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Yujin Jiang🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Bo Li🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Xinyu Zhu🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Chenxin Li🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Chufeng Gu🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Wenjun Zou🇨🇳Jiangnan University; Wuxi No.2 People's Hospital
- Zhi Jie Zheng🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Shuzhi Zhao🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recreational screen time (RST) has been found to be associated with cognitive decline and neurodegenerative diseases. However, the association between RST and age-related macular degeneration (AMD), an ocular neurodegenerative disease, is still unclear. We aimed to elucidate the association between RST and AMD.
Methods
This study consisted of three parts: 1) a prospective cohort study with 482 939 UK Biobank participants and a 12.8-year median follow-up to explore the association between RST and incident AMD; 2) a two-sample Mendelian randomisation (MR) analysis using summary-level genome-wide association analysis data for RST based on 526 725 European individuals to assess causality between RST and AMD; and 3) a cross-sectional study involving 38 478 UK Biobank individuals with optical coherence tomography data to investigate the link between RST and retinal thickness.
Results
Multivariable Cox proportional-hazards models showed that an increase in total daily RST was associated with a greater risk of developing AMD (hazard ratio (HR) per standard deviation (SD) increase = 1.05; 95% confidence interval (CI) = 1.03, 1.07, P 4 h/d) significantly increased the risk of AMD compared with low RST (0-3 h/d) (HR = 1.09; 95% CI = 1.04, 1.15, P = 0.001), while moderate RST (3.5-4 h/d) had no significant effect on AMD. Restricted cubic spline plots revealed a linear dose-response association between RST and AMD. With MR analysis we confirmed the potential causal association between RST and AMD (odds ratio per SD = 1.26; 95% CI = 1.01, 1.59, P = 0.042). Multivariable linear models suggested that an increase in RST was associated with thinning of the outer and inner retinal layers and total macular thickness.
Conclusions
Longer RST may be a potential causal risk factor for AMD and may lead to pathological retinal thinning. Reducing RST could be beneficial for preventing AMD, and future research should identify the most effective time points for intervening on RST.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.