Bioavailability and pharmacokinetics of (poly)phenols following consumption of selected blueberries and a blueberry-rich protein bar by adult males and females: a randomized, crossover, controlled trial
Santana MC, Rathore AS, Chandra P, Everhart JL, Schulz H, Granillo CD, Ferruzzi MG, Iorizzo M, Lila MA, Diaz JT, Kay CD
The American journal of clinical nutrition · 3 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Foundation for Food and Agriculture Research
- Gobierno
- National Institute of Food and Agriculture
- Subvenciones
- Foundation for Food and Agriculture Research (534667); National Institute of Food and Agriculture (02936)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2025-01-31 · Am J Clin Nutr · vol. 121 · número 4 · págs. 779–794
- Editorial
- Elsevier BV
- Citado
- 6 citas · más que el 89% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Pomegranate: compositions and health benefits · Berry genetics and cultivation research
- Palabras clave
- blueberry, polyphenols, bioavailability, pharmacokinetics, food processing, protein bars, urinary recovery, bioaccessibility, Cmax, Tmax, sex differences
- MeSH
- humans, fruit, phenols, cross-over studies, biological availability, adult, middle aged, female, male, young adult, polyphenols, blueberry plants
11 autores
- Monique Carvalho de Santana🇺🇸North Carolina State University
- Atul Rathore🇺🇸North Carolina State University
- Preeti A. Chandra🇺🇸North Carolina State University
- Jessica Everhart🇺🇸North Carolina State University
- Harry Schulz🇺🇸North Carolina State University
- Cheryl D Granillo🇺🇸North Carolina State University
- Mário G. Ferruzzi🇺🇸Arkansas Children's Nutrition Center; University of Arkansas for Medical Sciences
- Massimo Iorizzo🇺🇸North Carolina State University
- Mary Ann Lila🇺🇸North Carolina State University
- Joscelin T. Diaz🇺🇸North Carolina State University
- Colin D. Kay🇺🇸 · autor de correspondenciaArkansas Children's Nutrition Center; University of Arkansas for Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
It is commonly believed that higher nutrient content equates to healthier foods and that food processing lowers nutrient content, although bioavailability studies often indicate otherwise. Blueberries, a rich source of (poly)phenols with proven health benefits, provide a feasible model to evaluate phytochemical bioavailability following consumption of raw and processed fruits.
Objectives
This study evaluates the effect of processing on the bioavailability of (poly)phenols following consumption of 4 interventions: 2 blueberry varieties (i.e., Elliott and Olympia) selected based on differing (poly)phenol content and in vitro bioaccessibility, a (poly)phenol-rich protein bar providing an equivalent amount of blueberries, and a control beverage.
Methods
This blinded, randomized, 4-way crossover, controlled trial (n = 18; 42.06 ± 12.53 y; body mass index [BMI] 24.75 ± 2.97 kg/m2) fed 1 serving (150 g) of Elliott and Olympia blueberries and a (poly)phenol-rich protein bar containing 1 serving of Elliott blueberries, compared with a macronutrient-matched control beverage. (Poly)phenols and metabolites were analyzed in blood and urine over 48 h, with bioavailability and pharmacokinetics assessed via linear mixed-effects repeated measures ANOVA.
Results
Recovery of metabolites was similar following consumption of blueberry varieties of differing (poly)phenol composition, with higher total urinary recovery after Elliott blueberry relative to Olympia blueberry and protein bar (21% and 29%, respectively). Serum AUC was similar across berry-derived treatments, whereas differences in maximum concentration (Cmax) and time at maximum concentration (Tmax) were observed; for example, urinary recovery of 3-methoxycinnamic acid-4-O-glucuronide was similar following Elliott blueberry and protein bar (P = 1.00), whereas Cmax was 1.24 h later after Elliott blueberry compared with protein bar (Tmax = 3.84 compared with 2.60 h). Alternatively, Cmax for 3-(3-hydroxyphenyl)propanoic acid was higher following Elliott blueberry compared with Olympia blueberry and protein bar (26.63 and 25.32 ng/mL higher, respectively).
Conclusions
Differing berry (poly)phenol content and bioaccessibility only minimally affect bioavailability following consumption of blueberries relative to a blueberry-rich protein bar, suggesting (poly)phenol-dense foods, such as bars and snacks, could provide similar health benefits as raw fruits. Further studies using other crops are required to assess if these findings are translatable. This trial was registered at clinicaltrials.gov as NCT04175106.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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