The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials
Hariri M, Sohrabi M, Gholami A
Nutrition journal · 4 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Neyshabur University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-02-04 · Nutr J · vol. 24 · número 1 · pág. 24
- Editorial
- BioMed Central
- Citado
- 8 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 77 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Clinical nutrition, Meta-analysis, Randomized controlled trial, Lipidology, Internal medicine, Magnesium, Clinical chemistry, Lipid profile, Pharmacology, Cholesterol
- MeSH
- humans, magnesium, cholesterol, lipids, triglycerides, dose-response relationship, drug, dietary supplements, adult, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic
3 autores
- Mitra Hariri🇮🇷University of Neyshabur; Non-Communicable Diseases Research Center; Neyshabur University of Medical Sciences
- Masoudreza Sohrabi🇮🇷Firoozgar General Hospital
- Ali Gholami🇮🇷 · autor de correspondenciaUniversity of Neyshabur; Non-Communicable Diseases Research Center; Neyshabur University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Some evidence suggests magnesium might reduce serum levels of lipid profile. Due to the significance of this matter on hand, we centralized our aim to conduct a systematic review and meta-analysis to interrogate the effect of magnesium supplementation on serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) in the general population aged ≥ 18 years.
Methods
In line with conducting this study first, relevant articles were found through searching databases, including five databases: Cochrane Library, ClinicalTrials.gov, ISI Web of Science, Scopus, and PubMed until January 2024. Following fulfilling the first aim, their mean differences and standard deviations were calculated to conduct the meta-analysis. Ultimately, an assessment of the statistical heterogeneity of intervention effects was performed using I-squared statistics and Cochran's Q test.
Results
Regarding serum levels of TC, TG, LDL-C, and HDL-C, twenty-one, twenty-three, twenty, and twenty-five studies were included in the meta-analysis. The pooled estimates showed no significant differences in serum levels of TC, TG, and LDL-C between the magnesium group and comparison group (weighted mean difference (WMD) = 0.34 mg/dl, 95% confidence interval (CI): -1.75 to 2.43, P = 0.749, I2 = 99.1%; WMD=-2.06 mg/dl, 95% CI: -6.35 to 2.23, P = 0.346, I2 = 99.1; WMD = 1.71 mg/dl, 95% CI: -0.81 to 4.24, P = 0.183, I2 = 99.4, respectively). However, magnesium significantly increased HDL-C (WMD = 1.21 mg/dl, 95% CI: 0.58 to 1.85, P 2 = 99.5).
Conclusion
In conclusion, our study showed that magnesium significantly increased HDL-C levels. However, due to high heterogeneity, we must note that more research is needed to make robust recommendations regarding magnesium supplementation in clinical practice.
Registry number
This study was registered in PROSPERO under the protocol number CRD42024505142.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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