The Effect of Intermittent Fasting Diet in Comparison With Low-Calorie Diet on Inflammation, Lipid Profile, Glycemic Index, Liver Fibrosis in Patients With Metabolic-Associated Fatty Liver Disease (MAFLD): A Randomized Controlled Trial
Karimi M, Akhgarjand C, Houjaghani H, Nejad MM, Sohrabpour AA, Poustchi H, Mohammadi H, Chamari M, Imani H
Clinical therapeutics · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-02-05 · Clin Ther · vol. 47 · número 4 · págs. e9–e16
- Editorial
- Elsevier BV
- Citado
- 12 citas · más que el 98% de estudios similares · 7.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Dietary Effects on Health · Diet, Metabolism, and Disease
- Palabras clave
- metabolic-associated fatty liver disease, intermittent fasting, 16:8 fasting, hypocaloric diet, hepatic steatosis, liver fibrosis, lipid profile, triglycerides, inflammation, oxidative stress, glycemic index, dietary intervention
- MeSH
- humans, fatty liver, liver cirrhosis, inflammation, lipids, treatment outcome, caloric restriction, fasting, single-blind method, glycemic index, adult, middle aged, female, male, intermittent fasting
9 autores
- Mehdi Karimi🇮🇷Tehran University of Medical Sciences
- Camellia Akhgarjand🇮🇷Tehran University of Medical Sciences
- Hirad Houjaghani🇮🇷Iran University of Medical Sciences
- Maryam Mofidi Nejad🇮🇷Tehran University of Medical Sciences
- Amir Ali Sohrabpour
- Hossein Poustchi🇮🇷Digestive Disease Research Institute; Tehran University of Medical Sciences
- Hamed Mohammadi🇮🇷Tehran University of Medical Sciences
- Maryam Chamari🇮🇷Tehran University of Medical Sciences
- Hossein Imani🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Metabolic-associated fatty liver disease (MAFLD) is a prevalent condition with significant health and economic burdens. Dietary interventions, such as intermittent fasting (IF) and low-calorie diets (LCD), have shown promise in managing MAFLD, but their comparative efficacy remains unclear.
Methods
This 10-month, parallel, single-blind randomized controlled trial compared the effects of a 16:8 IF diet with an LCD on 52 patients with MAFLD. Anthropometric, biochemical, liver enzyme, steatosis, fibrosis, inflammatory, and oxidative status parameters were assessed before and after the interventions.
Results
Both diets led to improvements in anthropometric measures and liver enzyme levels, with no significant differences between groups. However, the LCD group showed superior outcomes in reducing liver steatosis (-52.40 vs -44.63 dB/m; P < 0.001) and fibrosis (-0.74 vs -0.004 Kpa; P = 0.01) compared to the IF group. LCD also led to a significant decrease in serum triglycerides (-24.08 vs 11.22 mg/dL; P = 0.02), while neither intervention significantly affected inflammatory markers or oxidative status.
Conclusion
While both IF and LCD can be effective in managing MAFLD, LCD may offer additional benefits in terms of liver fat reduction and improvement in certain lipid parameters. These findings highlight the complexity of dietary interventions in MAFLD and the need for personalized approaches.
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