Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial
Shafiee M, Sadeghi A, Ghafouri-Taleghani F, Nilghaz M, Ghods M, Narimani B, Hekmatdoost A, Saidpour A
Scientific reports · 12 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-02-06 · Sci Rep · vol. 15 · número 1 · pág. 4463
- Editorial
- Nature Portfolio
- Citado
- 13 citas · más que el 97% de estudios similares · 7.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease
- Palabras clave
- metabolic-associated fatty liver disease, time-restricted feeding, 16:8 fasting, lacto-ovo-vegetarian diet, weight loss, obesity, insulin resistance, liver enzymes, TNF-α, lipid profile, triglycerides, HDL cholesterol, dietary intervention
- MeSH
- humans, fatty liver, obesity, insulin, body mass index, diet, vegetarian, adult, middle aged, female, male, overweight, waist circumference, intermittent fasting
8 autores
- Mahshad Shafiee🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Amir Sadeghi🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Fateme Ghafouri-Taleghani🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Maryam Nilghaz🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Maryam Ghods🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Behnaz Narimani🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Azita Hekmatdoost🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Atoosa Saidpour🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight and obese patients with MAFLD. Forty-six participants were randomly assigned to either the intervention group (TRF with LOV diet) or the control group, with 21 participants completing the 12-week study in each group. The intervention group showed significant reductions in weight (-8.07 ± 4.31 kg), BMI (-2.70 ± 1.32 kg/m2), waist circumference (-8.00 ± 4.06 cm), as well as ALT (-17.14 ± 14.33 U/L), GGT (-21.09 ± 24.06 U/L), Fatty Liver Index (-26.90 ± 15.81), insulin levels (-3.89 ± 4.69 mU/L), and TNF-α (-11.85 ± 12.52 pg/mL) compared to the control group (all P < 0.05). Lipid profiles also improved with a reduction in triglycerides (-46.85 ± 54.55 mg/dL) and an increase in HDL-C (3.91 ± 5.07 mg/dL) in the intervention group compared to the control group (P < 0.05). These findings imply that TRF combined with a LOV diet enhances metabolic markers, liver health, and weight loss, thus potentially offering a practical dietary approach for managing MAFLD. Further long-term studies are necessary to validate these results and investigate their clinical applications.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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