Dietary Cholesterol and Myocardial Infarction in the Million Veteran Program
Nguyen XT, Li Y, Nyaeme MS, Panigrahy N, Houghton S, Ivey KL, Shiekh S, Willett WC, Hu FB, Gaziano JM, Wilson PWF, Cho K, Djousse L, VA Million Veteran Program
Journal of the American Heart Association · 1 cita
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Gobierno
- BLRD VA
- Gobierno
- CSRD VA
- Subvenciones
- U.S. Department of Veterans Affairs (I01 BX003340); U.S. Department of Veterans Affairs (HSR RES 13-457); U.S. Department of Veterans Affairs (I01-BX004821); U.S. Department of Veterans Affairs (I01 CX001025); U.S. Department of Veterans Affairs (RES 13-457)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-02-08 · J Am Heart Assoc · vol. 14 · número 4 · pág. e036819
- Editorial
- Wiley
- Citado
- 2 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Fatty Acid Research and Health
- Palabras clave
- Medicine, Myocardial infarction, Cholesterol, Internal medicine, Relative risk, Coronary artery disease, Cohort, Cohort study, High cholesterol, Incidence (geometry), Cardiology, Confidence interval
- MeSH
- humans, myocardial infarction, cholesterol, dietary, incidence, risk assessment, risk factors, prospective studies, databases, factual, aged, middle aged, veterans, united states, female, male
14 autores
- Xuan‐Mai T. Nguyen🇺🇸 · autor de correspondenciaUniversity of California, Los Angeles; VA Boston Healthcare System
- Yanping Li🇺🇸Harvard University; VA Boston Healthcare System
- Mark S. Nyaeme🇺🇸University of Illinois Urbana-Champaign; Illinois College
- Neha Panigrahy
- Serena C. Houghton🇺🇸VA Boston Healthcare System
- Kerry Lee Ivey🇺🇸VA Boston Healthcare System
- Shamlan Shiekh🇺🇸VA Boston Healthcare System
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- J. Michael Gaziano🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- Peter W.F. Wilson🇺🇸Emory University; Atlanta Medical Center; Atlanta VA Medical Center
- Kelly Cho🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- Luc Djoussé🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- the VA Million Veteran Program
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Coronary artery disease is a leading cause of morbidity and mortality in the United States. Coronary artery disease can lead to major complications including myocardial infarction (MI). The association of dietary cholesterol with coronary artery disease remains inconsistent. We examined the relation of dietary cholesterol with the incidence of MI among participants of the Million Veteran Program.
Methods and results
The Million Veteran Program is a prospective cohort database collecting genetic and nongenetic factors influencing chronic diseases. We analyzed data from 180 156 veterans with complete information on relevant dietary intake. The association between dietary cholesterol and MI risk was assessed using both linear and nonlinear models. Statistical significance was determined using the Wald test for linear trends and the likelihood ratio test for nonlinearity, alongside comparisons between high (≥300 mg/d) and low (300 mg/d of cholesterol had a 15% increased MI risk compared with those consuming less (RR, 1.15 [95% CI, 1.06-1.25]).
Conclusions
We found that dietary cholesterol intake was linearly associated with greater risk of MI. These findings contribute to the growing literature highlighting the impact dietary cholesterol has on cardiovascular health. Reductions in cholesterol intake, which can be achieved by decreasing the intake of meat and eggs, may reduce the risk of incident MI.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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