The Impact of Low Serum Magnesium Levels on COVID-19 Severity and Potential Therapeutic Benefits of Magnesium Supplementation: A Systematic Review
Majumder MH, Sazzad S, Hasin R, Brishti TJ, Tabassum FN, Ahamed T, Masud AA, Akter F
Cureus · 2 citas
Cómo se estudió
- Diseño
- Revisión sistemática (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-01-08 · Cureus · vol. 17 · número 1 · pág. e77118
- Editorial
- Cureus, Inc.
- Citado
- 1 cita · más que el 36% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Pancreatitis Pathology and Treatment · Trace Elements in Health
- Palabras clave
- Medicine, Hypermagnesemia, Coronavirus disease 2019 (COVID-19), Magnesium, Internal medicine, Disease, Hypomagnesemia
8 autores
- Mehrab Hasan Majumder🇺🇸🇧🇩Indiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
- Sadman Sazzad🇺🇸🇧🇩 · autor de correspondenciaIndiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
- Rabeya Hasin🇺🇸🇧🇩Indiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
- Tasnim Jabbar Brishti🇧🇩Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College
- Fateha Nadia Tabassum🇺🇸🇧🇩Indiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
- Tanvir Ahamed🇺🇸🇧🇩Indiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
- Abdullah Al Masud🇺🇸🇧🇩Indiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
- Fahima Akter🇺🇸🇧🇩Indiana University Health; Bangladesh Medical University; Ball Memorial Hospital; Ibrahim Cardiac Hospital & Research Institute; Ibrahim Medical College; Saint Louis University; Indiana University – Purdue University Indianapolis; Dhaka Medical College and Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
In this review, our objective was to analyze the association between serum magnesium (Mg) levels, Mg supplementation, and coronavirus disease 2019 (COVID-19) outcomes. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching major databases until February 2023. Twenty-six studies (11,363 patients) were included: 22 examining serum Mg levels (8474 patients) and four investigating Mg supplementations (2889 patients). Most studies indicated an association between lower serum Mg levels and increased COVID-19 severity, including higher mortality rates and prolonged recovery periods. Critical patients demonstrated significantly lower Mg levels compared to moderate/severe cases. However, some studies reported conflicting findings, with hypermagnesemia also associated with poor outcomes in specific patient populations. Regarding supplementation, higher dietary Mg intake correlated with shorter hospitalization duration and faster recovery. Mg supplementation exceeding 450 mg showed potential benefits, including increased antibody titers in pregnant women and reduced oxygen support requirements in elderly patients when combined with vitamins D and B12. While evidence suggests a potential relationship between Mg status and COVID-19 outcomes, findings are heterogeneous. Further investigation through well-designed clinical trials is required to gain deeper insights into the role of Mg in COVID-19 pathophysiology and the therapeutic potential of Mg supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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