A randomized clinical trial to evaluate the efficacy of cognitive rehabilitation and music therapy in mild cognitive impairment in Huntington's disease
Moreu-Valls A, Puig-Davi A, Martinez-Horta S, Kulisevsky G, Sampedro F, Perez-Perez J, Horta-Barba A, Olmedo-Saura G, Pagonabarraga J, Kulisevsky J
Journal of neurology · 6 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-02-11 · J Neurol · vol. 272 · número 3 · pág. 202
- Editorial
- Springer Science+Business Media
- Citado
- 7 citas · más que el 88% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · PUBLIC-DOMAIN
- Áreas de investigación
- Genetic Neurodegenerative Diseases · Dementia and Cognitive Impairment Research · Music Therapy and Health
- Palabras clave
- Huntington's disease, mild cognitive impairment, cognitive rehabilitation, music therapy, computerized cognitive training, non-pharmacological treatment, brain atrophy, caudate and putamen, inferior frontal gyrus, functional connectivity, default mode network, frontoparietal network, neuropsychiatric symptoms, neuroplasticity
- MeSH
- humans, huntington disease, magnetic resonance imaging, treatment outcome, music therapy, single-blind method, adult, middle aged, female, male, cognitive dysfunction, cognitive behavioral therapy, cognitive training
10 autores
- Andrea Moreu-Valls🇪🇸Universitat Autònoma de Barcelona; Hospital de Sant Pau; Institut de Recerca Sant Pau
- Arnau Puig‐Davi🇪🇸Universitat Autònoma de Barcelona; Hospital de Sant Pau; Institut de Recerca Sant Pau
- Saül Martínez‐Horta🇪🇸Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
- Gabriel Kulisevsky🇪🇸Hospital de Sant Pau; Institut de Recerca Sant Pau
- Frederic Sampedro🇪🇸Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
- Jesús Pérez‐Pérez🇪🇸Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
- Andrea Horta‐Barba🇪🇸Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
- Gonzalo Olmedo‐Saura🇪🇸Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
- Javier Pagonabarraga🇪🇸Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
- Jaime Kulisevsky🇪🇸 · autor de correspondenciaUniversitat Autònoma de Barcelona; Hospital de Sant Pau; Biomedical Research Networking Center on Neurodegenerative Diseases; Institut de Recerca Sant Pau
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cognitive impairment is a core feature of Huntington's disease (HD), yet no disease-modifying or symptomatic interventions have demonstrated efficacy in addressing these deficits. Non-pharmacological interventions, particularly cognitive training (CT), are promising options for maintaining neural plasticity, enhancing cognition, and improving emotional well-being.
Methods
This 24-week, single-center, randomized, single-blind study evaluated the safety and efficacy of two cognitive rehabilitation strategies in early-to-middle-stage HD patients. Participants were randomized into a computerized cognitive training (CT; n = 13) intervention or a music therapy (MT; n = 16) intervention. A standard of care (SoC; n = 15) group with no active intervention was also involved. Weekly 45-min sessions were conducted. Baseline and endpoint assessments included measures of global cognition, functional, motor, and neuropsychiatric assessments, along with structural and functional neuroimaging.
Results
Both CT and MT groups demonstrated significant improvements in primary and secondary cognitive endpoints, including global cognition an composite measures of disease severity. Regression analysis identified longitudinal cognitive score changes as independent predictors of the rate of atrophy in the caudate, putamen, and inferior frontal gyrus. Functional connectivity analysis showed distinct intervention-related effects: CT group exhibited increased connectivity between the central executive and sensorymotor networks, while MT group reduced aberrant connectivity between the central executive and the default-mode network.
Conclusion
This is the first randomized-controlled trial to evaluate two cognitive rehabilitation strategies in HD using multimodal neuroimaging. Both interventions were effective in improving cognition and modulating structural and functional brain changes in regions critical to HD. Trial Registration ClinicalTrials.gov (ID: NCT05769972).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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