Financiado en parte por Almond Board of California
Almond consumption for 8 weeks differentially modulates metabolomic responses to an acute glucose challenge compared to crackers in young adults
Dhillon J, Pandey S, Newman JW, Fiehn O, Ortiz RM
Nutrition research (New York, N.Y.) · 1 cita
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- Almond Board of California
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Minority Health and Health Disparities
- Subvenciones
- U.S. Department of Agriculture (2032‐51530‐025‐00D); National Institute on Minority Health and Health Disparities (R00MD012815)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2025-01-08 · Nutr Res · vol. 135 · págs. 67–81
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 62% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Diet, Metabolism, and Disease · Nutrition, Genetics, and Disease
- Palabras clave
- almond consumption, oral glucose tolerance test, serum metabolomics, unsaturated triglycerides, oxylipins, endocannabinoids, Matsuda index, dietary intervention, young adults, lipid metabolism, amino acid metabolism
- MeSH
- humans, nuts, blood glucose, triglycerides, endocannabinoids, glucose tolerance test, diet, adolescent, female, male, oxylipins, metabolomics, young adult, snacks, prunus dulcis
5 autores
- Jaapna Dhillon🇺🇸 · autor de correspondenciaUniversity of California, Merced; University of Missouri
- Saurabh Pandey🇮🇳🇺🇸Jaypee University of Information Technology; University of Missouri
- John W. I. Newman🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Oliver Fiehn🇺🇸University of California, Davis
- Rudy Martin Ortiz🇺🇸University of California, Merced
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study investigated the dynamic responses to an acute glucose challenge after 8 weeks of almond or cracker consumption (clinicaltrials.gov ID: NCT03084003). Young adults (n = 73, age: 18-19 years, BMI: 18-41 kg/m2) participated in an 8-week randomized, controlled, parallel-arm intervention and were assigned to consume either almonds (2 oz/d, n = 38) or an isocaloric control snack of graham crackers (325 kcal/d, n = 35) daily. Twenty participants from each group underwent a 2-hour oral glucose tolerance test (oGTT) at the end of the intervention. Metabolite abundances in the oGTT serum samples were quantified using untargeted metabolomics, and targeted analyses for free PUFAs, total fatty acids, oxylipins, and endocannabinoids. We hypothesized that 8-week almond consumption would differentially modulate the metabolomic response to a glucose challenge compared to crackers. Multivariate, univariate, and chemical enrichment analyses were conducted to identify significant metabolic shifts. Findings exhibit a biphasic lipid response with higher levels of unsaturated triglycerides earlier in the oGTT followed by lower levels later in the almond vs cracker group (p-value 120 min of aminomalonate, and oxylipins (P-value 120 min of l-cystine, N-acetylmannosamine, and isoheptadecanoic acid (P-value 120 min of CE 22:6 (r = -0.46; P-value <.05) and 12,13 DiHOME (r = 0.45; P-value <.05). Almond consumption for 8 weeks leads to dynamic, differential shifts in response to an acute glucose challenge, marked by alterations in lipid and amino acid mediators involved in metabolic and physiological pathways.
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