Financiado en parte por Dexcom
Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial
Oldenburg N, Mashek DG, Harnack L, Wang Q, Manoogian ENC, Evanoff N, Dengel DR, Taddese A, Yentzer BP, Lysne L, Wong A, Hanson M, Anderson JD, Alvear A, LaPage N, Ryder J, Varady K, Gao Z, Ryu S, Bolan PJ, Bergman B, Helgeson E, Panda S, Chow LS
Obesity (Silver Spring, Md.) · 24 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- Robert Wood Johnson Foundation
- Universidad u hospital
- University of Minnesota
- Empresa
- Dexcom
- Universidad u hospital
- Georgia Clinical and Translational Science Alliance
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Biomedical Imaging and Bioengineering
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- UMN CTSA Award
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIBIB NIH HHS
- Subvenciones
- National Institute of Biomedical Imaging and Bioengineering (P41 EB027061); National Institute of Diabetes and Digestive and Kidney Diseases (S10OD017974); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK124484); National Institutes of Health (1s10od017974-01); National Center for Advancing Translational Sciences (UM1TR004405); Robert Wood Johnson Foundation (76014); National Institute of Diabetes and Digestive and Kidney Diseases (P41EB027061)
Según 13 financiadores declarados.
Publicación
- Publicado
- 2025-02-19 · Obesity (Silver Spring) · vol. 33 · número 4 · págs. 671–684
- Editorial
- Wiley
- Citado
- 27 citas · más que el 99% de estudios similares · 14.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
- Palabras clave
- Medicine, Glycemic, Weight loss, Internal medicine, Caloric theory, Randomized controlled trial, Endocrinology, Obesity, Insulin
- MeSH
- humans, obesity, body weight, weight loss, blood glucose, absorptiometry, photon, body mass index, glucose clamp technique, caloric restriction, fasting, body composition, energy metabolism, energy intake, adult, middle aged, female, male, glycated hemoglobin
24 autores
- Niki C. Oldenburg🇺🇸University of Minnesota
- Douglas G. Mashek🇺🇸University of Minnesota
- Lisa Harnack🇺🇸University of Minnesota
- Qi Wang🇺🇸University of Minnesota
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- Nicholas G. Evanoff🇺🇸University of Minnesota
- Donald R. Dengel🇺🇸University of Minnesota
- Abdisa Taddese🇺🇸University of Minnesota
- Brad A. Yentzer🇺🇸University of Minnesota
- LESIA F. LYSNE🇺🇸University of Minnesota
- Alison Wong🇺🇸University of Minnesota
- Michelle J. Hanson🇺🇸University of Minnesota
- Julie D. Anderson🇺🇸University of Minnesota
- ALISON C. ALVEAR🇺🇸University of Minnesota
- Nicole LaPage🇺🇸University of Minnesota
- Justin R. Ryder🇺🇸Northwestern University; Lurie Children's Hospital
- Krista A Varady🇺🇸Illinois College; University of Illinois Chicago
- Zan Gao🇺🇸Knoxville College; University of Tennessee at Knoxville
- Suryeon Ryu🇺🇸University of Minnesota
- Patrick J. Bolan🇺🇸University of Minnesota
- Bryan C. Bergman🇺🇸University of Colorado Anschutz
- Erika S. Helgeson🇺🇸University of Minnesota
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Lisa Senye Chow🇺🇸 · autor de correspondenciaUniversity of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.
Methods
In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).
Results
Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m2; 54.5% female, 84.1% White). Final eating windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 h (95% CI: 11.9 to 13.9) for CR, and 11.8 h (95% CI: 11.0 to 12.7) for UE. Compared with UE (n = 29), weight changes were -1.4 kg (95% CI: -4.5 to 1.7; p = 0.53) with TRE (n = 30) and -2.5 kg (95% CI: -5.8 to 0.8; p = 0.18) with CR (n = 29). TRE showed lower metabolic flexibility than CR (-0.041 [95% CI: -0.080 to -0.002]). Weight, body composition, caloric intake, and glycemic measures were similar among groups. Eating window reduction correlated with decreased caloric intake and visceral fat.
Conclusions
In a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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