Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial
Hayes E, Alhulaefi S, Siervo M, Whyte E, Kimble R, Matu J, Griffiths A, Sim M, Burleigh M, Easton C, Lolli L, Atkinson G, Mathers JC, Shannon OM
European journal of nutrition · 15 citas
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- Financiación independiente
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- Wellcome Trust
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- The Wellcome Trust Translational Partnership
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-02-24 · Eur J Nutr · vol. 64 · número 2 · pág. 101
- Editorial
- Springer Science+Business Media
- Citado
- 16 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Blood Pressure and Hypertension Studies
- Palabras clave
- dietary nitrate, beetroot juice, blood pressure, nitric oxide bioavailability, plasma nitrate, plasma nitrite, interindividual variability, hypertension, healthy men
- MeSH
- humans, beta vulgaris, nitrates, nitrites, nitric oxide, cross-over studies, double-blind method, blood pressure, dietary supplements, adult, male, young adult, biomarkers, fruit and vegetable juices
14 autores
- Eleanor Jayne Hayes🇬🇧Northumbria University; Newcastle University
- Shatha S. Alhulaefi🇸🇦🇬🇧Taif University; Newcastle University
- Mario Siervo🇦🇺Curtin University
- Eleanor Whyte🇬🇧Newcastle upon Tyne Hospitals NHS Foundation Trust; Freeman Hospital
- Rachel Kimble🇬🇧University of the West of Scotland
- Jamie Matu🇬🇧Leeds Beckett University
- Alex Griffiths🇬🇧Leeds Beckett University
- Marc Sim🇦🇺Edith Cowan University; The University of Western Australia
- Mia C. Burleigh🇬🇧University of the West of Scotland
- Chris Easton🇬🇧University of the West of Scotland
- Lorenzo Lolli🇬🇧Manchester Metropolitan University
- Greg Atkinson🇬🇧Liverpool John Moores University
- John Cummings Mathers🇬🇧Newcastle University
- Oliver Michael Shannon🇬🇧 · autor de correspondenciaNewcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been investigated using robust designs, e.g., replicate crossover, and appropriate statistical models. We examined the within-individual consistency of the effects of dietary nitrate supplementation on NO biomarkers and BP, and quantified inter-individual response differences.
Methods
Fifteen healthy males visited the laboratory four times. On two visits, participants consumed 140 ml nitrate-rich beetroot juice (~ 14.0mmol nitrate) and, on the other two visits, they consumed 140 ml nitrate-depleted beetroot juice (~ 0.03mmol nitrate). Plasma nitrate and nitrite concentrations were measured 2.5 h post-supplementation. BP was measured pre- and 2.5 h post-supplementation. Between-replicate correlations were quantified for the placebo-adjusted post-supplementation plasma nitrate and nitrite concentrations and pre-to-post changes in BP. Within-participant linear mixed models and a meta-analytic approach estimated participant-by-condition treatment response variability.
Results
Nitrate-rich beetroot juice supplementation elevated plasma nitrate and nitrite concentrations and reduced systolic (mean:-7mmHg, 95%CI: -3 to -11mmHg) and diastolic (mean:-6mmHg, 95%CI: -2 to -9mmHg) BP versus placebo. The participant-by-condition interaction response variability from the mixed model was ± 7mmHg (95%CI: 3 to 9mmHg) for systolic BP and consistent with the treatment effect heterogeneity t = ± 7mmHg (95%CI: 5 to 12mmHg) derived from the meta-analytic approach. The between-replicate correlations were moderate-to-large for plasma nitrate, nitrite and systolic BP (r = 0.55 to 0.91).
Conclusions
The effects of dietary nitrate supplementation on NO biomarkers and systolic BP varied significantly from participant to participant. The causes of this inter-individual variation deserve further investigation.
Trial registration
https://clinicaltrials.gov/study/NCT05514821 .
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