The efficacy of DASH combined with time-restricted feeding (16/8) on metabolic associated fatty liver disease management: a randomized controlled trial
Nilghaz M, Sadeghi A, Koochakpoor G, Poustchi H, Khodadadi N, Narimani B, Ghods M, Shafiee M, Shahparvari MR, Hekmatdoost A
Scientific reports · 14 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
- Subvenciones
- Shahid Beheshti University of Medical Sciences (4300661)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-02-27 · Sci Rep · vol. 15 · número 1 · pág. 7020
- Editorial
- Nature Portfolio
- Citado
- 15 citas · más que el 98% de estudios similares · 9.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Dietary Effects on Health · Diet, Metabolism, and Disease
- Palabras clave
- metabolic-associated fatty liver disease, time-restricted feeding, DASH diet, dietary intervention, hepatic steatosis, liver fibrosis, insulin resistance, obesity, abdominal circumference, controlled attenuation parameter, alanine aminotransferase, aspartate aminotransferase, hypocaloric diet
- MeSH
- humans, insulin resistance, alanine transaminase, body mass index, treatment outcome, adult, middle aged, female, male, non-alcoholic fatty liver disease, dietary approaches to stop hypertension
10 autores
- Maryam Nilghaz🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Amir Sadeghi🇮🇷 · autor de correspondenciaResearch Institute for Gastroenterology and Liver Diseases; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Glareh Koochakpoor🇮🇷Maragheh University of Medical Sciences
- Hossein Poustchi🇮🇷Digestive Disease Research Institute; Tehran University of Medical Sciences
- Navideh Khodadadi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Behnaz Narimani🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Maryam Ghods🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Mahshad Shafiee🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Mohammad Reza Shahparvari🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Azita Hekmatdoost🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recent studies have utilized time-restricted feeding (16/8) (TRF) and dietary approaches to stop hypertension separately to manage metabolic-associated fatty liver disease (MAFLD); however, the effectiveness of combining these two approaches has not been investigated. The objective of this study was to examine the impact of TRF in conjunction with a DASH diet on various factors related to MAFLD. A 12-week randomized controlled trial was conducted to assess the impact of TRF (16/8), along with a DASH diet, compared with a control diet based on standard meal distribution, in patients with MAFLD. An investigation was conducted to examine alterations in anthropometric indices, as well as liver parameters, serum metabolic indices, and an inflammatory marker. The TRF plus DASH diet reduced body mass index (p = 0.03), abdominal circumference (p = 0.005), controlled attenuation parameter (CAP) (p < 0.001), alanine aminotransferase (p = 0.039), and aspartate aminotransferase (0.047) compared to the control group. The levels of insulin and homeostasis model assessment of insulin resistance reduced in both groups significantly (P < 0.05). In MAFLD patients, TRF (16/8) in combination with a DASH diet is superior to a low-calorie diet in promoting obesity indices, and hepatic steatosis and fibrosis. Further long-term investigations are needed to draw definitive conclusions.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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