Combined effects of time-restricted eating and exercise on short-term blood glucose management in individuals with Type 2 Diabetes Mellitus: The TREx study, a randomised controlled trial
Bravo-Garcia AP, Radford BE, Hall RC, Broome SC, Tee N, Arthur B, Janssens K, Johnston RD, Halson SL, Devlin BL, Hawley JA, Parr EB
Diabetes research and clinical practice · 1 cita
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-03-08 · Diabetes Res Clin Pract · vol. 222 · pág. 112081
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diabetes Management and Research · Diabetes Treatment and Management
- Palabras clave
- time-restricted eating, type 2 diabetes, blood glucose, insulin, chrononutrition, eating window, walking exercise, glycemic control
- MeSH
- humans, diabetes mellitus, type 2, insulin, blood glucose, exercise, fasting, cross-over studies, adult, aged, middle aged, female, male
12 autores
- Ana Paula Bravo-García🇦🇺Australian Catholic University
- Bridget E. Radford🇦🇺Australian Catholic University
- Rebecca C. Hall🇦🇺Australian Catholic University
- Sophie C. Broome🇦🇺Australian Catholic University
- Nicolin Tee🇦🇺Australian Catholic University
- Bronte Arthur🇦🇺Australian Catholic University
- Kristel Janssens🇦🇺Australian Catholic University
- Rich D. Johnston🇬🇧🇦🇺Leeds Beckett University; Australian Catholic University
- Shona Leigh Halson🇦🇺Australian Catholic University
- Brooke L. Devlin🇦🇺The University of Queensland
- John Alan Hawley🇬🇧🇦🇺Manchester Metropolitan University; Australian Catholic University
- Evelyn B. Parr🇦🇺 · autor de correspondenciaAustralian Catholic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
Time-restricted eating (TRE) is a chrono-nutrition strategy where the daily 'eating window' is reduced to 8-10 h. We investigated the acute (14-h) effects of TRE, with and without post-meal exercise, on blood glucose and insulin concentrations in people with type 2 diabetes mellitus.
Methods
Fourteen participants (5 F, 9 M; HbA1c: 7.6 ± 1.0%) completed four conditions in this randomised crossover study: CON (eating window, 0800-2000 h), CON with exercise (CON + Ex; 0800-2000 h + 15 min walking at 60% VO2peak, 45 min post-meal), TRE (eating window 1000-1800 h), and TRE with exercise (TRE + Ex, 1000-1800 h + 15 min walking as per CON + Ex), with standardised meals. Venous blood samples were collected at 26-timepoints and analysed for glucose and insulin concentrations. Statistical analysis used linear mixed-effects models with P < 0.05.
Results
Reducing the eating window had little effect on plasma glucose 14-h area under the curve (AUC). Exercise reduced insulin 14-h AUC (P=0.01) with no additive effect of TRE.
Conclusion
Post-meal exercise lowered 14-h insulin AUC, neither 8-h TRE nor post-meal exercise altered 14-h blood glucose compared with 12-h eating window. Future work should focus on long-term effects of TRE combined with exercise for enhancing blood glucose in people with type 2 diabetes mellitus.
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