Financiado en parte por New Capstone, Inc.
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial
Bomar MC, Ewell TR, Brown RL, Brown DM, Kwarteng BS, Abbotts KSS, Butterklee HM, Williams NNB, Wrigley SD, Walsh MA, Hamilton KL, Thomson DP, Weir TL, Bell C
Nutrients · 4 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- New Capstone, Inc.
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-03-06 · Nutrients · vol. 17 · número 5 · pág. 915
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 6 citas · más que el 90% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 85 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Nutrition and Health in Aging
- Palabras clave
- Crossover study, Cycle ergometer, Randomized controlled trial, Skeletal muscle, Medicine, Magnesium, Mitochondrion, Internal medicine, Physical therapy, Endocrinology, Physiology, Biology, Chemistry, Pathology, Biochemistry, Blood pressure, Placebo
- MeSH
- muscle, skeletal, mitochondria, muscle, humans, magnesium chloride, magnesium, exercise test, exercise, cross-over studies, double-blind method, oxygen consumption, dietary supplements, adult, female, male, athletic performance, young adult, gastrointestinal microbiome
14 autores
- Matthew Charles Bomar🇺🇸Colorado State University
- Taylor R. Ewell🇺🇸Colorado State University
- Reagan L. Brown🇺🇸Colorado State University
- David M. Brown🇺🇸Colorado State University
- Beatrice S. Kwarteng🇺🇸Colorado State University
- Kieran Shay Struebin Abbotts🇺🇸Colorado State University
- Hannah Michelle Butterklee🇺🇸Colorado State University
- Natasha N. Bondareva Williams🇺🇸Colorado State University
- Scott D. Wrigley🇺🇸Colorado State University
- Maureen A. Walsh🇺🇸Colorado State University
- Karyn L. Hamilton🇺🇸Colorado State University
- David P. Thomson🇺🇸Colorado State University
- Tiffany L. Weir🇺🇸 · autor de correspondenciaColorado State University
- Christopher P. Bell🇺🇸 · autor de correspondenciaColorado State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Although the importance of magnesium for overall health and physiological function is well established, its influence on exercise performance is less clear. The primary study objective was to determine the influence of short-term magnesium supplementation on cycle ergometer exercise performance. The hypothesis was that magnesium would elicit an ergogenic effect. Methods: A randomized, double-blind, placebo-controlled, two-period crossover design was used to study men and women who were regular exercisers. Fifteen participants ingested either a placebo or magnesium chloride (MgCl2 300 mg) twice per day, for 9 days, separated by a 3-week washout. During days 8 and 9, participants completed a battery of cycle ergometer exercise tests, and whole blood, vastus lateralis, and stools were sampled. The primary outcomes were the maximal oxygen uptake (VO2max), a simulated 10 km time trial, and the sprint exercise performance. Additional outcomes included skeletal muscle mitochondrial respiration, and, on account of the known laxative effects of magnesium, the gut microbiota diversity. Results: Compared with a placebo, MgCl2 supplementation increased the circulating ionized Mg concentration (p 2max (44.4 ± 7.7 vs. 41.3 ± 8.0 mL/kg/min; p = 0.005), and decreased the mean power output during a 30 s sprint (439 ± 88 vs. 415 ± 88 W; p = 0.03). The 10 km time trial was unaffected (1282 ± 126 vs. 1281 ± 97 s; p = 0.89). In skeletal muscle, MgCl2 decreased mitochondrial respiration in the presence of fatty acids at complex II (p = 0.04). There were no significant impacts on the gut microbiota richness (CHAO1; p = 0.68), Shannon's Diversity (p = 0.23), or the beta-diversity (Bray-Curtis distances; p = 0.74). Conclusions: In summary, magnesium supplementation had modest ergolytic effects on cycle ergometer exercise performance and mitochondrial respiration. We recommend that regular exercisers, free from hypomagnesemia, should not supplement their diet with magnesium.
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