Trimethylamine N-Oxide Plasma Levels Following Red Meat and Cod Fish Intake: A Pilot Crossover Trial in Hemodialysis Patients
Manhães LM, Santana L, Alves MR, Leal PM, de Velasco PC, Santana I, de Brito JS, Mafra D, Borges NA
Molecular nutrition & food research · 2 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Subvenciones
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/202.524/2019); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/211.440/2019)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-03-13 · Mol Nutr Food Res · vol. 69 · número 8 · pág. e70031
- Editorial
- Wiley
- Citado
- 4 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dialysis and Renal Disease Management · Gut microbiota and health · Nutritional Studies and Diet
- Palabras clave
- Trimethylamine N-oxide, Crossover study, Red meat, Food science, Hemodialysis, Trimethylamine, Fish <Actinopterygii>, Medicine, Kidney disease, Internal medicine, Animal science, Chemistry, Physiology, Endocrinology, Biology, Biochemistry, Fishery, Pathology
- MeSH
- animals, gadus morhua, humans, methylamines, renal dialysis, diet, pilot projects, cross-over studies, seafood, aged, middle aged, female, male, renal insufficiency, chronic, red meat
9 autores
- Larissa de Mattos Manhães🇧🇷Universidade do Estado do Rio de Janeiro
- L. C. L. A SANTANA🇧🇷Universidade do Estado do Rio de Janeiro
- Marcelo Ribeiro Alves
- Priscila Mansur Leal🇧🇷Hospital Universitário Pedro Ernesto
- Patricia Coelho de Velasco🇧🇷Universidade do Estado do Rio de Janeiro
- Isabelle Santana🇧🇷Universidade do Estado do Rio de Janeiro
- Jessyca Sousa de Brito🇧🇷Universidade Federal do Rio de Janeiro
- Denise Mafra🇧🇷Universidade Federal do Rio de Janeiro; Universidade Federal Fluminense
- Natália Alvarenga Borges🇧🇷 · autor de correspondenciaUniversidade do Estado do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
The uremic toxin trimethylamine N-oxide (TMAO) accumulates in patients with chronic kidney disease (CKD) and is associated with its progression, cardiovascular disease, and other complications. The gut microbiota produces TMAO from substrates mainly found in red meat, eggs, and dairy. However, some saltwater fish also contain high levels of TMAO. Although fish consumption is generally linked to beneficial effects, its effects on CKD patients require further research.
Methods and results
This study compares the effect of red meat and cod fish intake on TMAO plasma levels in CKD patients undergoing hemodialysis (HD). Participants received a single animal protein source (red meat vs. cod fish) for lunch and dinner for four consecutive days (each intervention), with a 2-week washout period in between. TMAO plasma levels were analyzed using LC-MS/MS. All 14 patients concluded the red meat intervention, while one refused to participate in the fish intervention. No significant difference in TMAO plasma levels was found post-red meat (p = 0.21) or fish intervention (p = 0.91), as well as between groups (p = 0.43).
Conclusion
In this study, 4 days of red meat and cod fish intake did not significantly impact TMAO levels in HD patients, while other factors may be associated with their circulating levels.
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