BEETter AGING: Short-Term Dietary Nitrate Supplementation Enhances Muscle Contractile Properties in Older But Not in Young Adults
Rasica L, Colosio M, Ferri A, Baldassarre G, Easton C, Burleigh M, Vernillo G, Bottinelli R, Marzorati M, Porcelli S
Medicine and science in sports and exercise · 4 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-03-18 · Med Sci Sports Exerc · vol. 57 · número 8 · págs. 1721–1731
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 5 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Muscle Physiology and Disorders
- Palabras clave
- nitrate supplementation, beetroot juice, muscle aging, skeletal muscle contractile properties, muscle fatigue, fatigue resistance, calcium handling, nitrite, plantar flexors, time to exhaustion, force-frequency relationship, older adults
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, nitrites, electric stimulation, aging, muscle fatigue, muscle contraction, isometric contraction, dietary supplements, adult, aged, female, male, young adult, fruit and vegetable juices
10 autores
- Letizia Rasica🇨🇦University of Lethbridge
- Marta Colosio🇮🇹University of Milan; University of Pavia
- Alessandra Ferri🇦🇺Victoria University
- Giovanni Baldassarre🇮🇹University of Udine
- Chris Easton🇬🇧University of the West of Scotland
- Mia C. Burleigh🇬🇧University of the West of Scotland
- Gianluca Vernillo🇨🇦🇮🇹University of Alberta; University of Milan
- Roberto Bottinelli🇮🇹University of Pavia
- Mauro Marzorati🇮🇹Institute of Biomedical Technologies; National Research Council
- Simone Porcelli🇮🇹 · autor de correspondenciaUniversity of Pavia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Dietary nitrate (NO 3- ) supplementation has been shown to improve skeletal muscle contractile function and reduce fatigue, potentially due to alterations in skeletal muscle Ca 2+ handling/sensitivity. Because aging muscle can have impaired Ca 2+ handling, the aim of the study was to evaluate the effects of dietary NO 3- supplementation on muscle contractile properties in young and older adults.
Methods
Eleven older (69 ± 4 yr, O) and 11 young (26 ± 2 yr, YG) adults consumed either NO 3- -rich beetroot juice (BR) or placebo (PLA), for 7 d. After supplementations, plantar flexors of dominant leg were evaluated as follow: a) maximal voluntary isometric contraction (MVIC), b) potentiated single twitches (Tw pot ) and double twitches electrical stimulations at the frequency of 100 Hz (Db 100 ) on the tibial posterior nerve, c) a fatigue isometric (70% of MVIC) test until exhaustion. The force-frequency relationship was assessed with trains of electrical pulses across a wide range of frequencies on the muscle belly of the nondominant leg.
Results
BR supplementation increased plasma [NO 3- ] and nitrite [NO 2- ] in both O and YG compared with PLA (more than sevenfold; all P ≤ 0.02). No changes were observed in MVC, Tw pot , and Db 100 force after BR compared with PLA in both YG and O. Only in O, Db 100 area under the curve (-7 ± 6 N·s change from PLA) and half relaxation time (-0.05 ± 0.06 s change from PLA) were significantly reduced, and time to exhaustion (+32 ± 43 s change from PLA) was significantly longer (all P < 0.02) after BR. In O, BR also significantly increased submaximal force produced by trains of electrical pulses ( P < 0.001).
Conclusions
NO 3- supplementation positively affects muscle contractile proprieties, submaximal electrically evoked force production, and fatigue resistance in older adults, whereas these positive results were not found in young.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.