Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials
Norouzzadeh M, Hasan Rashedi M, Ghaemi S, Saber N, Mirdar Harijani A, Habibi H, Mostafavi S, Sarv F, Farhadnejad H, Teymoori F, Khaleghian M, Mirmiran P
Nutrition journal · 4 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-03-24 · Nutr J · vol. 24 · número 1 · pág. 47
- Editorial
- BioMed Central
- Citado
- 11 citas · más que el 87% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 180 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Sodium Intake and Health · Medical and Biological Ozone Research
- Palabras clave
- Medicine, Confidence interval, Blood pressure, Internal medicine, Clinical nutrition, Randomized controlled trial, Meta-analysis, Nitrite, Pulse wave velocity, Gastroenterology, Endocrinology, Nitrate
- MeSH
- humans, hypertension, nitrates, nitrites, diet, blood pressure, dose-response relationship, drug, adult, middle aged, female, male, randomized controlled trials as topic, biomarkers
12 autores
- Mostafa Norouzzadeh🇮🇷Iran University of Medical Sciences
- Minoo Hasan Rashedi🇮🇷Iran University of Medical Sciences
- Shadi Ghaemi🇮🇷Tehran University of Medical Sciences
- Niloufar Saber🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Artemiss Mirdar Harijani🇮🇷Iran University of Medical Sciences
- Hamzeh Habibi🇮🇷Iran University of Medical Sciences
- Soroush Mostafavi🇮🇷Iran University of Medical Sciences
- Fatemeh Sarv🇮🇷Iran University of Medical Sciences
- Hossein Farhadnejad🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Farshad Teymoori🇮🇷 · autor de correspondenciaIran University of Medical Sciences; Tehran University of Medical Sciences
- Mohsen Khaleghian🇮🇷 · autor de correspondenciaIran University of Medical Sciences; Rasool Akram Hospital
- Parvin Mirmiran🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Hypertension and vascular dysfunction are major health concerns, and studies have suggested different interventions, including dietary nitrate (NO3), to improve it. We sought to elucidate the effects of dietary NO3 on plasma NO3 and nitrite (NO2) levels and to determine the shape of the effect of dietary NO3 on blood pressure (BP) and vascular health biomarkers.
Methods
PubMed, Scopus, and Web of Science were searched up to February 2024 for eligible randomized controlled trials (RCTs). The pooled results were reported as weighted mean differences (WMD) and 95% confidence intervals (CIs).
Results
Our analysis of 75 RCTs involving 1823 participants revealed that per each millimole (mmol) increase in the administered NO3 dose, both acute (WMD: 32.7µmol/L; 95%CI: 26.1, 39.4) and chronic-term (WMD: 19.6µmol/L; 95%CI: 9.95, 29.3) plasma NO3 levels increased. Per each mmol increase in NO3 intake, a reduction in systolic BP levels was observed in the acute (WMD: -0.28mmHg; 95%CI: -0.40, -0.17), short-term (WMD: -0.24mmHg; 95%CI: -0.40, -0.07), and medium-term (WMD: -0.48mmHg; 95%CI: -0.71, -0.25) periods. Furthermore, a decrease in diastolic BP for each mmol increase in NO3 intake (WMD: -0.12 mmHg; 95% CI: -0.21, -0.03) was shown. Moreover, a linear dose-response relationship was indicated between each mmol of NO3 intake and medium-term pulse wave velocity (WMD: -0.07 m/s; 95%CI: -0.11, -0.03), medium-term flow-mediated dilation (WMD: 0.30%; 95%CI: 0.15, 0.46), and medium-term augmentation index (WMD: -0.57%; 95%CI: -0.98, -0.15).
Conclusion
We observed dose-dependent increases in plasma NO3 and NO2 levels, along with consequent reductions in BP and enhancements in vascular health following dietary NO3 supplementation. Future high-quality, population-specific studies with optimized dietary NO3 dosages are needed to strengthen the certainty of the evidence.
Registration
The protocol for this systematic review was registered in PROSPERO under the registration number CRD42024535335.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.