The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial
Catenacci VA, Ostendorf DM, Pan Z, Kaizer LK, Creasy SA, Zaman A, Caldwell AE, Dahle J, Swanson B, Breit MJ, Bing K, Wayland LT, Panter SL, Scorsone JJ, Bessesen DH, MacLean P, Melanson EL
Annals of internal medicine · 16 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK048520); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK111622); National Institute of Diabetes and Digestive and Kidney Diseases (F32DK122652); National Institute of Diabetes and Digestive and Kidney Diseases (F32 DK123878); National Heart, Lung, and Blood Institute (K24 HL169755); National Institutes of Health (UL1TR002535)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2025-03-31 · Ann Intern Med · vol. 178 · número 5 · págs. 634–644
- Editorial
- American College of Physicians
- Citado
- 19 citas · más que el 99% de estudios similares · 10.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Obesity, Physical Activity, Diet
- Palabras clave
- intermittent fasting, weight loss, obesity, overweight, behavioral weight loss program, caloric restriction, physical activity, long-term weight maintenance
- MeSH
- humans, obesity, weight loss, body mass index, caloric restriction, fasting, energy intake, adolescent, adult, middle aged, female, male, young adult, weight reduction programs, intermittent fasting
17 autores
- Victoria A. Catenacci🇺🇸 · autor de correspondenciaUniversity of Colorado Anschutz
- Danielle M. Ostendorf🇺🇸 · autor de correspondenciaUniversity of Colorado Anschutz; University of Tennessee at Knoxville
- Zhaoxing Pan🇺🇸University of Colorado Anschutz
- Laura K. Kaizer🇺🇸University of Colorado Anschutz
- Seth A. Creasy🇺🇸University of Colorado Anschutz
- Adnin Zaman🇺🇸University of Rochester Medicine; University of Colorado Anschutz; University of Rochester
- Ann E. Caldwell🇺🇸University of Colorado Anschutz
- Jared H. Dahle🇺🇸United States Air Force Academy
- Bryan Swanson🇺🇸University of Colorado Anschutz
- Matthew J. Breit🇺🇸University of Colorado Anschutz
- Kristen Bing🇺🇸University of Colorado Anschutz
- Liza T. Wayland🇺🇸University of Colorado Anschutz
- Shelby L. Panter🇺🇸University of Colorado Anschutz
- Jared J. Scorsone🇺🇸University of Colorado Anschutz
- Daniel H. Bessesen🇺🇸University of Colorado Anschutz
- Paul S. MacLean🇺🇸University of Colorado Anschutz
- Edward L. Melanson🇺🇸University of Colorado Anschutz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.
Objective
To compare the effects of 4:3 IMF versus DCR on changes in weight at 12 months, with comprehensive behavioral support provided to both groups.
Design
Randomized clinical trial. (ClinicalTrials.gov: NCT03411356).
Setting
Denver, Colorado, and surrounding metropolitan area.
Participants
Adults aged 18 to 60 years with body mass index (BMI) of 27 to 46 kg/m2.
Intervention
The IMF group was instructed to restrict energy intake by 80% on 3 nonconsecutive days per week, with ad libitum intake (no restriction) the other 4 days (4:3 IMF). The DCR group was instructed to reduce daily energy intake by 34% to match the weekly energy deficit of 4:3 IMF. Both groups received a high-intensity comprehensive behavioral weight loss program that included group-based behavioral support and a recommendation to increase moderate-intensity physical activity to 300 minutes per week.
Measurements
The primary outcome was change in body weight (in kilograms) at 12 months.
Results
Of the 165 (4:3 IMF, n = 84; DCR, n = 81) randomly assigned participants (mean age, 42 years [SD, 9]; mean BMI, 34.1 kg/m2 [SD, 4.4]; 73.9% female), 125 completed the trial. In an intention-to-treat analysis, 4:3 IMF showed greater reductions in weight than DCR at 12 months (mean difference, 2.89 kg [95% CI, 5.65 to 0.14 kg]; P = 0.040).
Limitation
Limited generalizability.
Conclusion
Compared with DCR, 4:3 IMF resulted in modestly greater weight loss among adults with overweight or obesity enrolled in a 12-month, high-intensity, comprehensive behavioral weight loss program.
Primary funding source
National Institute of Diabetes and Digestive and Kidney Diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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