Evaluation of Yograj Guggulu, Ashwagandha Churna and Narayana Taila in management of Osteoarthritis Knee: A study in tribal dominant community
Kachare K, Makhija D, Sharma A, Sunita, Srikanth N, Sharma BS, Rana R, Tripathi A, Rao BCS, Panda P, Ekta, Naik R, Nishanth K, Shekhar Namburi UR, Tiwari V, Singh SB, Monika, Srinivas P, Sharma V, Avhad A, Sinha A, Ravte R, Lal A, Rao K, Mashram P, Doddamani SH, Gopad S, Priya, Tiwari D, Mangal A, Kumawat VB, Prameela K, Subhash, Ram J, Sahu SK, Niral S, Abhaydev
Journal of Ayurveda and integrative medicine · 2 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India
- Universidad u hospital
- Iowa Energy Center
- Gobierno
- Ministry of AYUSH, Government of India
- Gobierno
- Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy
- Subvenciones
- Iowa Energy Center (CTRI/2021/07/034964)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-03-01 · J Ayurveda Integr Med · vol. 16 · número 2 · pág. 101077
- Editorial
- Elsevier BV
- Citado
- 7 citas · más que el 95% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Pharmacological Effects of Medicinal Plants · Phytochemicals and Medicinal Plants · Osteoarthritis Treatment and Mechanisms
- Palabras clave
- Medicine, Osteoarthritis, Traditional medicine, Physical therapy, Alternative medicine, Pathology
37 autores
- Kalpana Kachare🇮🇳 · autor de correspondenciaCentral Council for Research in Ayurvedic Science
- Deepa P Makhija🇮🇳Central Council for Research in Ayurvedic Science
- Abha Sharma🇮🇳Central Council for Research in Ayurvedic Science
- Sunita Sunita🇮🇳Central Council for Research in Ayurvedic Science; Ministry of AYUSH
- Narayanam Srikanth🇮🇳Central Council for Research in Ayurvedic Science
- BS Sharma🇮🇳Central Council for Research in Ayurvedic Science
- Rakesh Rana🇮🇳Central Council for Research in Ayurvedic Science
- Arunabh Tripathi🇮🇳Central Council for Research in Ayurvedic Science
- B C S Rao🇮🇳Central Council for Research in Ayurvedic Science
- Purnendu Panda🇮🇳Ministry of AYUSH
- Ekta🇮🇳Ministry of AYUSH
- Raghavendra Naik🇮🇳Ministry of AYUSH
- K Nishanth🇮🇳Ministry of AYUSH
- Uday RS Namburi🇮🇳Ministry of AYUSH
- Vimal Tiwari🇮🇳Ministry of AYUSH
- S. B. Singh🇮🇳Ministry of AYUSH
- Monika🇮🇳Ministry of AYUSH
- P. Srinivas🇮🇳Ministry of AYUSH
- Vipin Sharma🇮🇳Ministry of AYUSH
- Anil Avhad🇮🇳Ministry of AYUSH
- A. K. Sinha🇮🇳Ministry of AYUSH
- Rohit Kumar Ravte🇮🇳Ministry of AYUSH
- Akash Lal🇮🇳Ministry of AYUSH
- Krishna Rao🇮🇳Ministry of AYUSH
- Pravin Mashram🇮🇳Ministry of AYUSH
- Shridevi Doddamani🇮🇳Ministry of AYUSH
- Savita Gopad🇮🇳Ministry of AYUSH
- Priya🇮🇳Ministry of AYUSH
- Deepika Pandey Tiwari🇮🇳Ministry of AYUSH
- Anil K. Mangal🇮🇳Ministry of AYUSH
- Vasu Kumawat🇮🇳Ministry of AYUSH
- K. Prameela🇮🇳Ministry of AYUSH
- Subhash Subhash🇮🇳Central Council for Research in Ayurvedic Science; Ministry of AYUSH
- Jaiprakash Ram🇮🇳Ministry of AYUSH
- Santosh Kumar Sahu🇮🇳Ministry of AYUSH
- Sojeetra Niral🇮🇳Ministry of AYUSH
- Abhaydev🇮🇳Ministry of AYUSH
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Osteoarthritis (OA) is the most prevalent joint disease and a major cause of joint impairment and physical debility, common in elderly, women and laborious workers. The available non-steroidal anti-inflammatory drugs (NSAID) are being prescribed to manage the condition; however, newly discovered alternatives are looked upon by the practitioners. Thus, the study was aimed to provide an effective and safer alternative through Ayurveda for the management of OA.
Objective
To document the role of the selected Ayurveda formulations in the management of OA and to assess the tolerability of the formulations.
Material and methods
It was an open-label, multicentric, single-arm, prospective, study conducted at 14 peripheral institutes of the Central Council for Research in Ayurvedic Sciences, New Delhi. 483 participants of any gender between the age 40 to 65 years diagnosed with OA knee as per the ACR diagnostic criteria (2012) and willing to provide consent were enrolled in the study. Oral administration of Ayurvedic formulations Yograj Guggulu, Ashwagandha Churna and the local application of Narayana Taila was given for 12 weeks and assessment was done by means of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Modified-CRD, Pune version Score, Visual Analogue Scale score and disease-specific symptoms on 28th, 56th, 84th and 112th day.
Results
Significant change (P<0.001) was observed in WOMAC score, VAS score and cardinal symptoms of OA knee. No adverse events reported in the study and the study drugs were well tolerated by the participants.
Conclusion
The study substantiates that administration of Yograj guggulu, Ashwagandha Churna and Narayana Taila, is well acceptable and tolerable. The interventions effectively alleviate the cardinal symptoms of OA knee.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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