Inflammatory and lipemic response to red meat intake in women with and without Rheumatoid Arthritis: a single meal study within a randomized controlled trial
Sällström T, Bärebring L, Hulander E, Gjertsson I, Winkvist A, Lindqvist HM
BMC nutrition · 1 cita
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Vetenskapsrådet
- Universidad u hospital
- Göteborgs Universitet
- Gobierno
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Universidad u hospital
- University of Gothenburg
- Organización sin fines de lucro
- Magnus Bergvalls Foundation
- Gobierno
- Swedish government under the ALF agreement
- Subvenciones
- Vetenskapsrådet (2021-00954); Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2017-00318)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-04-11 · BMC Nutr · vol. 11 · número 1 · pág. 74
- Editorial
- BioMed Central
- Citado
- 1 cita · más que el 69% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Rheumatoid Arthritis Research and Therapies · Nutritional Studies and Diet · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Postprandial, Medicine, Rheumatoid arthritis, Internal medicine, Meal, Lipid profile, Very low-density lipoprotein, Endocrinology, Lipoprotein, Cholesterol, Clinical nutrition, Body mass index, Insulin
6 autores
- Torsten Sällström🇸🇪University of Gothenburg
- Linnea Bärebring🇸🇪University of Gothenburg
- Erik Hulander🇸🇪University of Gothenburg
- Inger Gjertsson🇸🇪University of Gothenburg
- Anna Winkvist🇸🇪University of Gothenburg
- Helen M. Lindqvist🇸🇪 · autor de correspondenciaUniversity of Gothenburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The risk of atherosclerotic cardiovascular disease (ASCVD) is increased in Rheumatoid Arthritis (RA). Previous research has suggested that lipid metabolism is altered in RA, but research under postprandial conditions is scarce. The aim of this study was to investigate whether women with RA have a different lipemic and inflammatory response to a mixed meal containing red meat compared to women without RA.
Methods
Twenty-two women with RA, with modest disease activity, and 22 women without RA matched for age and body mass index (BMI) at the group level consumed a hamburger meal containing ca. 700 kcal (53 E% from fat, 27 E% from carbohydrate). Venous blood was sampled in the fasted state and after 30 min, 1, 2, 3 and 5 h and analysed for lipid species using nuclear magnetic resonance spectroscopy. Postprandial inflammation was measured by interleukin- 6 (IL- 6). The postprandial lipid response was calculated as the incremental area under the curve minimal value, and serial measurements were analysed by repeated measures analysis of variance. Lipid and inflammatory responses were compared by linear regression analysis, adjusted for age, BMI, physical activity, and baseline plasma concentration.
Results
Plasma concentrations of IL- 6, triglycerides (TGs) and very low-density lipoprotein (VLDL) particles increased significantly after the meal compared to baseline within both groups, but no differences were observed between groups. However, the women with RA had a less pronounced response in cholesterol carried in VLDL particles (p = 0.03) and in TGs in the subfraction of VLDL particles with highest density (p = 0.03). No association was found between the response in TGs and IL- 6.
Conclusion
This study does not provide compelling evidence for any difference in the lipemic or inflammatory response in women with RA compared with age- and BMI-matched women without RA following ingestion of a mixed, high-fat meal containing red meat. The modest disease activity in women with RA should be considered when interpreting these findings. Subtle group differences found in the lipids carried by VLDL particles warrant further investigation.
Trial registration
The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial was registered 2020-01 - 28 at Clinicaltrials.gov (NCT04247009).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.