Influence of Intermittent Fasting on Body Composition, Physical Performance, and the Orexinergic System in Postmenopausal Women: A Pilot Study
Valenzano AA, Vasco P, D'Orsi G, Marzovillo RRR, Torquato M, Messina G, Polito R, Cibelli G
Nutrients · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Università degli Studi di Foggia
- Gobierno
- Miur
- Universidad u hospital
- University of Foggia Deparment of Clinical and Experimental Medicine
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-03-24 · Nutrients · vol. 17 · número 7 · pág. 1121
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 8 citas · más que el 94% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Cardiovascular and exercise physiology · Physical Activity and Health
- Palabras clave
- intermittent fasting, high-intensity interval training, hypocaloric diet, postmenopausal women, body composition, physical performance, orexin-A, orexin system, grip strength, 6-minute walk test, VO2max, flexibility, heart rate, endurance
- MeSH
- saliva, humans, absorptiometry, photon, hand strength, caloric restriction, fasting, pilot projects, body composition, postmenopause, heart rate, aged, middle aged, female, orexins, high-intensity interval training, physical functional performance, intermittent fasting
8 autores
- Anna Antonia Valenzano🇮🇹University of Foggia
- Paride Vasco🇮🇹University of Foggia
- Gabriella D’Orsi🇮🇹University of Foggia
- Raffaella R. R. Marzovillo🇮🇹University of Foggia
- M.T.C.G. Torquato🇮🇹University of Foggia
- Giovanni Messina🇮🇹University of Campania "Luigi Vanvitelli"
- Rita Polito🇮🇹Pegaso University
- Giuseppe Cibelli🇮🇹 · autor de correspondenciaUniversity of Foggia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective: This study aims to evaluate the effects of different nutritional strategies, specifically intermittent fasting (IF) combined with high-intensity interval training (HIIT) versus a low-calorie diet (LCD), on body composition, physical performance, and the orexinergic system in postmenopausal women. Methods: A randomized controlled trial involving thirty postmenopausal women (mean age 57.50 ± 6.50 years) was conducted over eight weeks, comparing the two dietary approaches alongside an 8-week HIIT program. Body composition was assessed using bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA). Performance metrics included handgrip strength and the 6-min walking test (6MWT). Salivary samples were analyzed for Orexin-A (OX-A) levels pre- and post-intervention. Results: Significant improvements in health metrics, such as heart rate (HR) and endurance, were found, with mean HR changes showing a significant difference (F = 5.943, p = 0.033) between the groups at T1. Orexin-A levels reflected significant metabolic regulation shifts in relation to other variables, showing a change from baseline to post-intervention values at T1 (F = 10,931, p = 0.033). Flexibility (sit and reach) significantly improved by 6% (p p Conclusions: The combination of IF and HIIT is an effective nutritional strategy for enhancing body composition and physical performance in postmenopausal women, potentially mediated by changes in the orexinergic system. Further research is warranted to explore long-term effects and underlying mechanisms.
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