Financiado en parte por U.S. Highbush Blueberry Council, U.S. Highbush Blueberry Council grant
Effects of Blueberry Consumption on Fecal Microbiome Composition and Circulating Metabolites, Lipids, and Lipoproteins in a Randomized Controlled Trial of Older Adults with Overweight or Obesity: The BEACTIVE Trial
Porter Starr KN, Connelly MA, Wallis J, North R, Zhang Q, Song K, González-Delgado JM, Brochu HN, Icenhour CR, Iyer LK, Miller MG, Huffman KM, Kraus WE, Bales CW
Nutrients · 5 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Grupo de la industria
- U.S. Highbush Blueberry Council grant
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-03-29 · Nutrients · vol. 17 · número 7 · pág. 1200
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Phytochemicals and Antioxidant Activities · Nutritional Studies and Diet
- Palabras clave
- fecal microbiota, dietary polyphenols, older adults, overweight and obesity, lipoproteins, cholesterol, HDL cholesterol, LDL cholesterol, apolipoproteins, cardiometabolic risk, supervised exercise, phytochemicals
- MeSH
- feces, humans, obesity, lipids, lipoproteins, diet, aged, middle aged, female, male, overweight, biomarkers, gastrointestinal microbiome, blueberry plants
14 autores
- Kathryn N. Porter Starr🇺🇸 · autor de correspondenciaDuke University; Duke Medical Center; Durham VA Medical Center
- Margery A. Connelly🇺🇸LabCorp (United States)
- Jessica Wallis🇺🇸Duke University; Duke Medical Center
- Rebecca North🇺🇸Duke University; Duke Medical Center
- Qimin Zhang🇺🇸LabCorp (United States)
- Kuncheng Song🇺🇸LabCorp (United States)
- Jessica M. González-Delgado🇺🇸LabCorp (United States)
- Hayden N. Brochu🇺🇸LabCorp (United States)
- Crystal R. Icenhour🇺🇸LabCorp (United States)
- Lakshmanan K. Iyer🇺🇸LabCorp (United States)
- Marshall G. Miller🇺🇸Duke University; Duke Medical Center
- Kim M. Huffman🇺🇸Duke University; Duke Medical Center
- William E. Kraus🇺🇸Duke University; Duke Medical Center
- Connie W. Bales🇺🇸Duke University; Duke Medical Center; Durham VA Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Generous consumption of phytonutrient-rich foods, including blueberries, provides benefits to multiple physiologic and metabolic systems. This study explored the potential that regular, generous blueberry intake could favorably modulate fecal microbiome composition in sedentary older (>60 years) men and women with overweight or obesity (BMI ≥ 25 to 32 kg/m2). Methods: Participants (n = 55) were randomized to daily consumption of either lyophilized blueberry powder (equivalent to 1.5 cups of blueberries) or an indistinguishable placebo powder; both groups participated in weekly supervised exercise classes. Fecal samples were collected at 0 and 12 weeks and frozen. Following this, 16S rRNA gene sequencing was used to profile each participant's fecal microbiome. Blood biomarkers of cardiometabolic health were measured via nuclear magnetic resonance spectroscopy (NMR) pre- and post-treatment. Results: Comparing the baseline and endpoint results for the blueberry (n = 15) and placebo (n = 19) groups, there were no significant overall compositional differences or differences in the level of diversity in the fecal microbiome. However, in subjects whose diet included blueberry powder, there was a significant enrichment (p = 0.049) in the relative abundance of Coriobacteriales incertae sedis, a taxonomic group of bacteria that facilitates the metabolism of dietary polyphenols. The placebo group exhibited significant reductions in total cholesterol, LDL-C, non-HDL-C, total LDL-P, large LDL-P, and ApoB, while the blueberry group exhibited significant reductions in total HDL-P and ApoA-I after 12 weeks compared to baseline. Conclusions: Generous blueberry consumption may upregulate the ability of the older human gut to utilize dietary polyphenols by altering the fecal microbiome. Longer, larger-scale studies with blueberries or blueberry powder are needed to observe improvements in cardiometabolic risk factors in older adults with overweight or obesity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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