Dietary magnesium intake affects the association between dietary vitamin A and depression: a cross-sectional study
Yan C, Gao C, Zhan K, Li C
Frontiers in nutrition · 1 cita
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-04-01 · Front Nutr · vol. 12 · pág. 1514681
- Editorial
- Frontiers Media
- Citado
- 2 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Medicinal Plants and Bioactive Compounds · Folate and B Vitamins Research
- Palabras clave
- Cross-sectional study, Medicine, Depression (economics), Environmental health, Micronutrient, Association (psychology), Food science, Psychology, Biology
4 autores
- Canqun Yan🇨🇳University of South China
- Conghui Gao🇨🇳University of South China
- Kebin Zhan🇨🇳 · autor de correspondenciaUniversity of South China
- Cheng Li🇨🇳 · autor de correspondenciaUniversity of South China
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Depression represents a significant global health burden, ranking as one of the leading causes of disability worldwide, and nutrition plays a key role in mental health. Vitamin A, essential for immune and neurological function, has shown conflicting associations with depression. Magnesium, essential for neurotransmission and neuroprotection, is associated with a reduced risk of depression. Importantly, magnesium is required for the activation of enzymes involved in vitamin A metabolism, suggesting a potential interaction between these nutrients in depression. However, this interaction remains poorly understood. This study investigates how magnesium intake modifies the relationship between vitamin A and depression, with the aim of elucidating their combined effects and informing personalized dietary strategies for depression prevention.
Research design and methods
Data for this study were extracted from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2016, involving a total of 60,936 participants. The final analysis included 25,277 adults aged ≥20 years (Female: 12,581, Male:12,696), excluding pregnant women, individuals under 20, and those with incomplete data. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), supplemented by self-reporting questionnaires. Dietary intake was assessed via a recall interview at the mobile examination center (MEC). Dietary vitamin A intake, treated as a continuous variable, was categorized based on the median intake value. Stratified analyses were conducted based on sex and magnesium intake levels (Female: low: <310 mg/day; high: ≥310 mg/day; Male: low: <400 mg/day; high: ≥400 mg/day).
Results
Our cross-sectional study showed that in women with low magnesium intake, higher vitamin A intake was associated with a reduced risk of depression (OR: 0.83, 95% CI: 0.76-0.92, p p-value for interaction = 0.145).
Conclusion
Our study suggests that a sex-specific interaction between dietary magnesium and vitamin A in modulating depression risk. This interaction highlights the potential role of combined nutritional interventions in depression management. Further randomized controlled trials are warranted to confirm these findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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