Early time-restricted eating with energy restriction has a better effect on body fat mass, diastolic blood pressure, metabolic age and fasting glucose compared to late time-restricted eating with energy restriction and/or energy restriction alone: A 3-month randomized clinical trial
Črešnovar T, Habe B, Mohorko N, Kenig S, Jenko Pražnikar Z, Petelin A
Clinical nutrition (Edinburgh, Scotland) · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Javna Agencija za Raziskovalno Dejavnost RS
- Gobierno
- Slovenian Research and Innovation Agency
- Subvenciones
- Javna Agencija za Raziskovalno Dejavnost RS (I0-0035); Javna Agencija za Raziskovalno Dejavnost RS (P1-0386); Javna Agencija za Raziskovalno Dejavnost RS (56962)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2025-04-08 · Clin Nutr · vol. 49 · págs. 57–68
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 99% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- time-restricted eating, caloric restriction, obesity, overweight, fat mass, diastolic blood pressure, metabolic age, fasting blood glucose, cardiometabolic risk factors, chronotype, sleep quality, quality of life, weight loss, fasting insulin, fasting lipids, resting metabolic rate, circadian rhythm
- MeSH
- humans, obesity, blood glucose, body mass index, caloric restriction, diet, reducing, fasting, blood pressure, time factors, adult, middle aged, female, male, overweight, cardiometabolic risk factors
6 autores
- Tanja Črešnovar🇸🇮 · autor de correspondenciaUniversity of Primorska
- Bernarda Habe🇸🇮 · autor de correspondenciaUniversity of Primorska
- Nina Mohorko🇸🇮 · autor de correspondenciaUniversity of Primorska
- Saša Kenig🇸🇮 · autor de correspondenciaUniversity of Primorska
- Zala Jenko Pražnikar🇸🇮 · autor de correspondenciaUniversity of Primorska
- Ana Petelin🇸🇮 · autor de correspondenciaUniversity of Primorska
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Time-restricted eating (TRE) has attracted increasing attention from researchers and the public. Recent studies suggest that the combination of TRE with energy restriction (ER) may have more favourable effects on both physical and biochemical aspects compared to ER alone. The aim of the present 3-month intervention study was to determine the effects of an 8-h early time-restricted eating and an 8-h late time-restricted eating with ER (eTRE + ER and lTRE + ER) compared to 12-h ER alone on body mass and other anthropometric and cardiometabolic risk factors in participants with overweight and obesity.
Methods
Participants (n = 108) were allocated to three different groups according to their personal chronotype: eTRE + ER (37 participants), lTRE + ER (37 participants) and ER (34 participants). Ninety-three participants completed the entire 3-month intervention (34 in eTRE + ER, 28 in lTRE + ER and 31 in ER). Anthropometric and cardiometabolic risk factors were measured at baseline and after 1, 2 and 3 months of the intervention. Sleep quality and quality of life were assessed at baseline and after 3 months of the intervention. ER was determined based on the individual's resting metabolic rate. Effects were analyzed using the per-protocol approach.
Results
Results showed a significant time main effect (p < 0.001), suggesting a decrease in body mass at the end of the 3-month intervention with a mean loss of -5.0 kg (95 % CI, -5.7, -4.3) for the eTRE + ER group, -4.4 kg (95 % CI, -5.2, -3.6) for the lTRE + ER group and -4.3 kg (95 % CI, -5.0, -3.6) for the ER group, with no significant difference between the groups (p = 0.319). eTRE + ER had greater improvements in fat mass (-1.2 % (95 % CI, -2.1, -0.2), p = 0.013) and fasting glucose (-0.35 mmol/L (95 % CI, -0.63, -0.06), p = 0.012) than participants in the lTRE + ER group and greater improvements in fat mass (-1.1 % (95 % CI, -2.0, -0.1), p = 0.022), metabolic age (-3 years (95 % CI, -5, -0), p = 0.028) and diastolic blood pressure (-4 mmHg (95 % CI, -8, -0), p = 0.033) than the participants in the ER group. No significant changes were found between the groups for the other parameters measured.
Conclusions
There was no difference in body mass between the eTRE + ER, lTRE + ER and ER groups after 3 months of intervention. However, eTRE + ER showed a greater benefit for fasting blood glucose, certain anthropometric parameters and diastolic blood pressure compared to lTRE + ER and/or ER alone. Other anthropometric, biochemical and health-related parameters were not affected by eating window.
Trial registration
https://clinicaltrials.gov/study/NCT05730231.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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