The Effect of Creatine Supplementation on Lean Body Mass with and Without Resistance Training
Desai I, Pandit A, Smith-Ryan AE, Simar D, Candow DG, Kaakoush NO, Hagstrom AD
Nutrients · 6 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Personas
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- Marcadores de salud y funcionamiento
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- Financiación independiente
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Publicación
- Publicado
- 2025-03-19 · Nutrients · vol. 17 · número 6 · pág. 1081
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 94% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Nutrition and Health in Aging
- Palabras clave
- creatine monohydrate, lean body mass, resistance training, body water content, sex differences, maintenance dose, muscle hypertrophy
- MeSH
- humans, creatine, absorptiometry, photon, body mass index, body composition, dietary supplements, adult, female, male, resistance training, young adult
7 autores
- Imtiaz Desai🇦🇺 · autor de correspondenciaUNSW Sydney; Neuroscience Research Australia
- Anurag Pandit🇦🇺UNSW Sydney
- Abbie E. Smith‐Ryan🇺🇸University of North Carolina at Chapel Hill
- David Simar🇦🇺UNSW Sydney
- Darren Glenn Candow🇨🇦University of Regina
- Nadeem Omar Kaakoush🇦🇺UNSW Sydney
- Amanda D. Hagstrom🇦🇺UNSW Sydney
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Creatine monohydrate (CrM) is considered to be one of the most effective supplements for enhancing lean body mass during resistance training. However, CrM may influence body water content, potentially confounding lean body mass measurements. Therefore, this randomised controlled trial assessed the effect of CrM alone on lean body mass following a supplement wash-in, and when combined with a resistance training program. Methods: Sixty-three (34 females, 29 males, 31 ± 8 years) participants were randomised to supplement with CrM (5 g/day for 13 weeks: wash-in + 12-week resistance training) or serve as a control (received no creatine or placebo). Lean body mass was measured using dual X-ray absorptiometry at baseline, post 7-day wash-in, and post 12 weeks of resistance training. Both groups began the same training program post CrM wash-in. Results: After the 7-day wash-in, the supplement group gained 0.51 ± 1.79 kg more lean body mass than the control group (p = 0.03). Following the wash-in, both groups gained 2 kg after resistance training (p p = 0.71). Sex-disaggregated analysis showed that the supplement group, only in females, gained 0.59 ± 1.61 kg more lean body mass than the controls (p = 0.04). There were no group differences in lean body mass growth following resistance training in females (p = 0.10) or males (p = 0.35). Conclusions: A 7-day CrM wash-in increased lean body mass, particularly in females. Thereafter, CrM did not enhance lean body mass growth when combined with resistance training, likely due to its short-term effects on lean body mass measurements. A maintenance dose of higher than 5 g/day may be necessary to augment lean body mass growth.
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