Comparative Effectiveness of Cinnarizine Versus Cinnarizine Plus Otic Bitter Almond Oil for Tinnitus: A Randomized Controlled Trial
Arabi M, Jokar A, Nikkhah M, Mousavinasab SN, Memariani Z, Heydari M, Mosavat SH
Alternative therapies in health and medicine · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-09-01 · Altern Ther Health Med · vol. 31 · número 5 · págs. 205–209
- Editorial
- National Institutes of Health
- Citado
- 0 citas · más que el 9% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Hearing, Cochlea, Tinnitus, Genetics · Hearing Loss and Rehabilitation · Vestibular and auditory disorders
- Palabras clave
- tinnitus, cinnarizine, bitter almond oil, adjuvant therapy, chronic tinnitus, tinnitus intensity, Tinnitus Handicap Inventory, Persian medicine
- MeSH
- humans, tinnitus, cinnarizine, plant oils, treatment outcome, adolescent, adult, aged, middle aged, iran, female, male, young adult, prunus dulcis
7 autores
- Maryam Arabi
- Assie Jokar
- Mehdi Nikkhah
- Seyed Nouraddin Mousavinasab
- Zahra Memariani
- Mojtaba Heydari
- Seyed Hamdollah Mosavat
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Tinnitus is a common auditory disorder and is often associated with anxiety, depression, sleep disturbances, and irritability. The shortcomings of current treatment options justify the exploration of additional treatment methods. Otic delivery of bitter almond oil has been suggested in traditional Persian medicine as a remedy for tinnitus.
Primary study objective
The study aimed to evaluate the efficacy and safety of bitter almond oil as an adjuvant in reducing the intensity of tinnitus.
Methods/design
Randomized controlled trial comparing the effectiveness of cinnarizine versus cinnarizine plus otic bitter almond oil for tinnitus.
Setting
The study was conducted at three medical centers, including Amir Alam Hospital, Imam Khomeini Hospital, and Baqiyatallah Hospital, affiliated with Mazandran University of Medical Sciences, Iran.
Participants
Sixty-nine individuals who met the inclusion criteria (providing written consent, being between 18 and 75 years old, and being diagnosed with chronic tinnitus by an otorhinolaryngology specialist), were enrolled in the study and randomly assigned to two groups.
Intervention
The intervention group received 2 drops of bitter almond oil into the ear and 25 mg of cinnarizine, while the control group received only 25 mg of cinnarizine twice daily for 4 weeks.
Primary outcome measures
Changes in tinnitus intensity were evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and Visual Analogue Scale (VAS) at the end of the 4-week treatment period.
Results
A significant difference was observed in total scores of VAS and THI after intervention in the experimental and control groups separately (P .05).
Conclusion
The adjuvant use of bitter almond oil possibly helps to achieve a greater reduction in the intensity of tinnitus over time.
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