Long-Term Consumption of Ultraprocessed Foods and Prodromal Features of Parkinson Disease
Wang P, Chen X, Na M, Flores-Torres MH, Bjornevik K, Zhang X, Chen X, Khandpur N, Rossato SL, Zhang FF, Ascherio A, Gao X
Neurology · 9 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- China Postdoctoral Science Foundation
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- Pan American Health Organization
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- NINDS NIH HHS
- Subvenciones
- National Institute of Neurological Disorders and Stroke (R01NS102735)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2025-05-07 · Neurology · vol. 104 · número 11 · pág. e213562
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 12 citas · más que el 98% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Parkinson's Disease Mechanisms and Treatments
- Palabras clave
- Parkinson's disease, Term (time), Consumption (sociology), Disease, Medicine, Environmental health, Pathology
- MeSH
- humans, parkinson disease, olfaction disorders, rem sleep behavior disorder, constipation, longitudinal studies, depression, adult, aged, middle aged, female, male, prodromal symptoms
12 autores
- Peilu Wang🇨🇳 · autor de correspondenciaFudan University
- Xiao Chen🇺🇸🇨🇳Harvard University; Fudan University; Massachusetts General Hospital
- Muzi Na🇺🇸Pennsylvania State University
- Mario H. Flores‐Torres🇺🇸Harvard University
- Kjetil Bjørnevik🇺🇸Harvard University
- Xuehong Zhang🇺🇸Harvard University; Yale University
- Xiqun Chen🇺🇸🇨🇳Harvard University; Fudan University; Massachusetts General Hospital
- Neha Khandpur🇺🇸🇧🇷🇳🇱Harvard University; Universidade de São Paulo; Wageningen University & Research
- Sinara Laurini Rossato🇺🇸🇧🇷Harvard University; Universidade Federal de Uberlândia
- Fang Fang Zhang🇺🇸Tufts University
- Alberto Ascherio🇺🇸Brigham and Women's Hospital; Harvard University
- Xiang Gao🇨🇳 · autor de correspondenciaFudan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Consumption of ultraprocessed foods (UPFs) has been associated with a higher risk of various chronic diseases, but its relation to prodromal Parkinson disease (PD) remains unclear. We aimed to assess the association between long-term UPF consumption and nonmotor features suggestive of prodromal PD.
Methods
This longitudinal analysis included participants without a history of PD from the Nurses' Health Study and Health Professionals Follow-Up Study. UPF consumption was assessed using repeated food frequency questionnaires (1984-2006) and grouped based on Nova classification. Participants provided data on probable REM sleep behavior disorder (pRBD) and constipation in 2012. Between 2014 and 2015, a subset of participants provided data on 5 additional nonmotor features, including hyposmia, impaired color vision, excessive daytime sleepiness, body pain, and depressive symptoms. The primary outcome was the combination of all 7 prodromal features and further categorized as 0 (reference), 1, 2, and ≥3 features. The secondary outcomes were all features except constipation, a combination of 3 commonly recognized features (constipation, pRBD, and hyposmia), and individual features. Multinomial logistic regression was used to estimate the association of UPF consumption with the combination of prodromal features. The association between UPF consumption and each individual feature was further examined using logistic regression.
Results
The study analyzed 42,853 participants (25,095 women [58.6%]; mean [SD] age, 47.8 [5.2] years). Comparing extreme quintiles of UPF consumption, the multivariable-adjusted odds ratio (OR) for having ≥3 vs 0 prodromal features was 2.47 (95% CI 1.89-3.23, ptrend ptrend = 0.0009) for baseline intake. Similar results were observed for combinations of all features except constipation (OR 2.00, 95% CI 1.29-3.11, ptrend ptrend = 0.008). In addition, higher UPF consumption was associated with increased odds of individual prodromal features, including pRBD, constipation, body pain, and depressive symptoms.
Discussion
Long-term UPF consumption was positively associated with nonmotor prodromal PD features. More studies are warranted to confirm whether lowering UPF consumption may prevent the occurrence of nonmotor symptoms that often precede PD diagnosis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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