Effects of intermittent fasting diet in overweight and obese postmenopausal women with rheumatoid arthritis: A randomized controlled clinical trial
Ranjbar M, Shab-Bidar S, Rostamian A, Mohammadi H, Tavakoli A, Djafarian K
Complementary therapies in medicine · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Subvenciones
- Tehran University of Medical Sciences and Health Services (1402-1-212-65311)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-05-10 · Complement Ther Med · vol. 91 · pág. 103189
- Editorial
- Elsevier BV
- Citado
- 8 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 99 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Rheumatoid Arthritis Research and Therapies · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, rheumatoid arthritis, postmenopausal women, obesity, overweight, disease activity, disability, inflammation, oxidative stress, C-reactive protein, erythrocyte sedimentation rate, interleukin-6, body mass index
- MeSH
- humans, arthritis, rheumatoid, obesity, body mass index, fasting, oxidative stress, postmenopause, quality of life, aged, middle aged, female, overweight, intermittent fasting
6 autores
- Mahsa Ranjbar🇮🇷Tehran University of Medical Sciences
- Sakineh Shab‐Bidar🇮🇷Tehran University of Medical Sciences
- Abdolrahman Rostamian🇮🇷Imam Khomeini Hospital; Tehran University of Medical Sciences
- Hamed Mohammadi🇮🇷Tehran University of Medical Sciences
- Aryan Tavakoli🇮🇷Tehran University of Medical Sciences
- Kurosh Djafarian🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Rheumatoid arthritis (RA), in the category of rheumatic diseases, is an autoimmune illness that affects joints and other parts of suffered patients. Intermittent fasting (IF) is a dietary pattern that has had beneficial impacts on several populations. This randomized controlled trial (RCT) hypothesized that IF can improve quality of life, clinical symptoms, inflammation, and oxidative stress in overweight and obese postmenopausal women with RA.
Method
This study was a controlled, parallel-group superiority design in which 44 overweight and obese postmenopausal women with RA were randomly allocated to receive either IF (n = 22) or the usual diet (n = 22) for 8 weeks. The intervention group received 16/8 IF, and the control group received the typical diet for 8 weeks. The primary outcome was the Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaire score. The secondary outcomes included body mass index (BMI) and morning joint stiffness (MS) and biochemical indicators, including serum concentrations of erythrocyte sedimentation rate (ESR), high sensitive c-reactive protein (hs-CRP), and total oxidant and antioxidant capacity (TOC and TAC), and oxidative stress index (OSI), and interleukin 6 (IL-6) were assessed at the baseline and end of the study. Disease severity was assessed using the Disease Activity Score-28 (DAS-28) and Clinical Disease Activity Index (CDAI).
Results
The IF diet significantly improved BMI, DAS-28, CDAI, and HAQ (p-value<0.05 for all). However, there were no significant effects on the other study outcomes.
Conclusion
IF has beneficial effects on some outcomes related to RA patients, while it has no significant impact on inflammation and oxidative stress markers. More studies are needed to determine IF's effects on RA patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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