Comparison of Different Intermittent Fasting Patterns or Different Extents of Calorie Restriction for Weight Loss and Metabolic Improvement in Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Wu X, Ding Y, Cao Q, Huang J, Xu X, Jiang Y, Xu Y, Lu J, Xu M, Wang T, Zhao Z, Wang W, Ning G, Bi Y, Li M
Nutrition reviews · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Innovative Research Team of High-level Local University in Shanghai
- Gobierno
- Science and Technology Commission of Shanghai Municipality
- Gobierno
- Shanghai Rising-Star Program
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- Shanghai Municipal Government
- Gobierno
- National Key R&D Program of China
- Universidad u hospital
- Innovative Research Team of High-Level Local Universities in Shanghai
- Gobierno
- Innovative Research Team of High-Level Local Universities in Shanghai, Science and Technology Commission of Shanghai Municipality
- Gobierno
- National Key R&D Program of China
- Subvenciones
- Science and Technology Commission of Shanghai Municipality (24DZ2307200); National Key Research and Development Program of China (2023YFC2506700); National Key Research and Development Program of China (2023ZD0508401); Shanghai Rising-Star Program (21QA1408100)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2025-03-31 · Nutr Rev · vol. 84 · número 3 · págs. 487–499
- Editorial
- Oxford University Press
- Citado
- 5 citas · más que el 70% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, continuous energy restriction, caloric restriction, weight loss, metabolic improvement, obesity, overweight, alternate-day fasting, blood pressure, serum lipids, glycemic control, weight regain, dietary intervention, adults, anthropometry, metabolic abnormalities, sleep duration, sleep efficiency
- MeSH
- humans, obesity, weight loss, caloric restriction, fasting, adult, middle aged, female, male, overweight, randomized controlled trials as topic, intermittent fasting, network meta-analysis as topic
15 autores
- Xianglin Wu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Yi Ding🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Qiuyu Cao🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Jiaojiao Huang🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Xiaoli Xu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Youjin Jiang🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Yu Xu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Jieli Lu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Jieli Lu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Tiange Wang🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Zhiyun Zhao🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Weiqing Wang🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Guang Ning🇨🇳Shanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Yufang Bi🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
- Mian Li🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Ruijin Hospital; State Key Laboratory of Medical Genomics
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Continuous energy restriction (CER) and intermittent fasting (IF) are both prevalent diet regimens recommended for weight loss and metabolic improvement.
Objective
The objective of this study was to evaluate the efficacy of CER and IF on weight loss and metabolic improvement in adults with overweight, obesity, or metabolic abnormalities.
Data sources
PubMed, Embase, and the Cochrane Library (CENTRAL) were searched for randomized controlled trials of 3 degrees of CER diet regimens and 4 categories of IF diet regimens, from inception of the databases to December 2022.
Data extraction
Two reviewers independently extracted demographic information, the intervention duration, details of the dietary interventions, and data on the outcomes of interest.
Data analysis
Bayesian random-effect network meta-analyses were used to pool the results and the Grading of Recommendations, Assessment, Development, and Evaluation framework was used to assess the certainty of the evidence and to present the findings.
Results
The study included 167 eligible trials with a total enrollment of 11 998 participants. Most IF diet regimens induced significant weight loss that was comparable with that induced by CER diet regimens with a similar absolute energy restriction, based on low- to high-certainty evidence. Severe CER proved to be the most effective regimen for obtaining weight loss, based on moderate-certainty evidence (mean difference of weight change 11.50 kg [95% CI 10.07 to 12.93]), followed by alternate-day fasting, based on high-certainty evidence (mean difference of weight change (5.07 kg [95% CI 3.44 to 6.72]) and moderate CER, based on moderate-certainty evidence (6.09 kg [95% CI 5.26 to 6.93]), when the regimens being compared were consistent in their absolute energy restriction extent. Similar results were noticed for body measurements, blood pressure, blood lipids, and glycemic profiles. In the subgroup analysis, the weight-loss effects of the IF but not the CER diet regimens experienced rebound after 12 weeks.
Conclusion
In adults with overweight, obesity, or metabolic abnormalities, effectiveness in weight loss mainly depends on the extent of the energy restriction, regardless of the mealtime patterns.
Systematic review registration
PROSPERO registration no. CRD42022379621.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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