Effect of intermittent fasting on obesity and metabolic indices in patients with metabolic syndrome: a systematic review and meta analysis
Zhang S, Sun B, Sun L, Zou S, Chen Q
BMC endocrine disorders · 4 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-05-14 · BMC Endocr Disord · vol. 25 · número 1 · pág. 130
- Editorial
- BioMed Central
- Citado
- 14 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- intermittent fasting, metabolic syndrome, obesity, continuous energy restriction, triglycerides, insulin resistance, weight loss, body mass index, blood pressure, dietary habits
- MeSH
- humans, insulin resistance, obesity, body mass index, caloric restriction, fasting, randomized controlled trials as topic, metabolic syndrome, intermittent fasting
5 autores
- Shengxuan Zhang🇨🇳Zhejiang Chinese Medical University; Hangzhou Hospital of Traditional Chinese Medicine
- Bixuan Sun🇨🇳Zhejiang Chinese Medical University; Hangzhou Hospital of Traditional Chinese Medicine
- Lei Sun🇨🇳Zhejiang Chinese Medical University; Hangzhou Hospital of Traditional Chinese Medicine
- Shijian Zou🇨🇳Zhejiang Chinese Medical University; Hangzhou Hospital of Traditional Chinese Medicine
- Qilan Chen🇨🇳 · autor de correspondenciaZhejiang Chinese Medical University; Hangzhou Hospital of Traditional Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Dietary patterns play a vital role in the health management of individuals with metabolic syndrome. Many recent studies have shown that intermittent fasting (IF) has better effects, such as improving obesity. Nevertheless, it warrants further investigation to determine which approach is more effective in comparison to continuous energy restriction (CR), particularly when total calorie intake shows minimal variation. Consequently, it is crucial to evaluate the degree of enhancement of the two dietary patterns concerning different aspects of metabolic syndrome. This study presents a meta-analysis of randomized controlled trials (RCTs) aimed at comparing the impacts of IF and CR on obesity and glucolipid metabolism in individuals diagnosed with metabolic syndrome.
Methods
In August 2024, a thorough examination of English-language literature was performed across the PubMed, Medline, Embase, and Cochrane Library databases. The meta-analyses was performed according to the established guidelines and reported the results. Weight change, Body Mass Index (BMI) change, and triglyceride (TG) level change were designated as key assessment indicators, while blood pressure, blood glucose, hip circumference, and waist circumference served as supplementary indicators for comparative analysis.
Result
A total of nine studies involving 626 patients were analyzed, focusing on the influence of dietary patterns on obesity, cholesterol levels, and insulin resistance among individuals diagnosed with metabolic syndrome. Both dietary patterns were beneficial for patients with metabolic syndrome. However, IF was better than CRin terms of improvement in obesity over the trial period (mean -1.77, 95% CI [-3.06, -0.48]), and it was more conducive to a reduction in TG levels, which was beneficial in terms of improving insulin resistance (mean -10.16, 95% CI [-18.88, -1.45]).
Conclusion
Given its notable advantages for obesity, lipids, and insulin resistance, along with improved patient adherence, IF may be regarded as a more effective dietary approach for individuals with metabolic syndrome. Nonetheless, the long-term effectiveness still necessitates additional validation.
Prospero registration
CRD42024587335.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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