Cruciferous vegetables improve glycaemic control compared to root/squash vegetables in a randomized, controlled, crossover trial: The VEgetableS for vaScular hEaLth (VESSEL) study
Connolly EL, Liu AH, Woodman RJ, Shafaei A, Wood LG, Mithen R, James AP, Schultz CJ, Gan SK, Bondonno CP, Lewis JR, Hodgson JM, Blekkenhorst LC
Diabetes, obesity & metabolism · 1 cita
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Edith Cowan University
- Gobierno
- Department of Health, Government of Western Australia
- Organización sin fines de lucro
- National Heart Foundation of Australia Post-Doctoral Research Fellowship
- Universidad u hospital
- Royal Perth Hospital Research Foundation
- Gobierno
- Western Australian Future Health Research and Innovation Fund
- Gobierno
- National Health and Medical Research Council of Australia
- Gobierno
- Department of Health Western Australia
- Gobierno
- Australian Government Research Training Program Scholarship
- Subvenciones
- Department of Health, Government of Western Australia (G1004519); Edith Cowan University (G1004405)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-05-15 · Diabetes Obes Metab · vol. 27 · número 8 · págs. 4300–4310
- Editorial
- Wiley
- Citado
- 0 citas · más que el 12% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Natural Antidiabetic Agents Studies
- Palabras clave
- cruciferous vegetables, glycemic control, postprandial glucose response, glycemic variability, vegetable soup, elevated blood pressure, non-diabetic adults, flash glucose monitoring, dietary intervention, type 2 diabetes prevention, cardiovascular disease prevention, older women, menopause, hormone replacement therapy, menopausal symptoms
- MeSH
- humans, brassica, vegetables, diabetes mellitus, type 2, blood glucose, cross-over studies, postprandial period, adult, aged, middle aged, female, male, meals, glycemic control
13 autores
- Emma L. Connolly🇦🇺Edith Cowan University
- Alex H. Liu🇦🇺Edith Cowan University
- Richard John Woodman🇦🇺Flinders University
- Armaghan Shafaei🇦🇺Edith Cowan University
- Lisa G. Wood🇦🇺University of Newcastle Australia
- Richard F. Mithen🇳🇿University of Auckland
- Anthony Paul James🇦🇺Curtin University
- Carl Johann Schultz🇦🇺The University of Western Australia; Royal Perth Hospital
- Seng Khee Gan🇦🇺The University of Western Australia; Royal Perth Hospital
- Catherine P. Bondonno🇦🇺Edith Cowan University; The University of Western Australia
- Joshua Richard Lewis🇦🇺Edith Cowan University; The University of Western Australia
- Jonathan M. Hodgson🇦🇺Edith Cowan University; The University of Western Australia
- Lauren C. Blekkenhorst🇦🇺 · autor de correspondenciaEdith Cowan University; The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
Higher cruciferous vegetable (e.g., broccoli) intake is associated with lower risk of type 2 diabetes and cardiovascular disease, but limited causal evidence exists. We investigated if cruciferous vegetable intake improved glycaemic control compared to root/squash vegetables in non-diabetic adults with elevated blood pressure.
Materials and methods
This randomized, controlled, crossover trial consisted of two 2-week dietary interventions (300 g/day cruciferous [active] and root/squash [control] soups with standardized lunch/dinner meals) separated by a 2-week washout. Participants were blinded to the intervention allocation. Glycaemic measures were a pre-specified secondary outcome. Flash glucose monitoring measured interstitial glucose every 15-min throughout both interventions. Mealtimes and consumption were recorded in food diaries. Differences in continuous glucose, glycaemic variability (coefficient of variation [CV]), and overall, lunch, and dinner postprandial glucose response (PPGR; 2-h mean glucose [PPGR 2-h] and area under the curve [AUC]) were assessed using linear mixed-effects regression.
Results
Eighteen participants (female = 89%) completed the study (median [IQR] age: 68 [66-70 years]). Glycaemic variability was lower in the active versus control (mean difference: -2.0%, 95% CI -2.8, -1.1, p < 0.001). Overall PPGR 2-h and AUC were lower in the active versus control (mean difference: -0.14 mmol/L, 95% CI -0.24, -0.04, p = 0.005 and -20.1 mmol/L × min, 95% CI -34.1, -6.1, p = 0.005, respectively), driven by the dinner PPGR (p = 0.004 and p = 0.003, respectively). There was no difference in mean continuous glucose for active versus control (p = 0.411).
Conclusions
Cruciferous vegetable consumption improved postprandial glycaemic control compared with root/squash vegetables. The clinical impact remains uncertain and warrants further investigation, particularly in individuals with impaired glycaemic control.
Clinical trial registry
This trial was registered at www.anzctr.org.au (ACTRN12619001294145).
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