Six weeks of time-restricted eating improves basal fat oxidation and body composition but not fat oxidation during exercise in young males
Aktaş H, Atakan MM, Aktitiz S, Ergün Z, Koşar ŞN, Astorino TA, Turnagöl HH
Clinical nutrition (Edinburgh, Scotland) · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-04-30 · Clin Nutr · vol. 50 · págs. 92–103
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Muscle metabolism and nutrition
- Palabras clave
- time-restricted eating, fat oxidation, basal metabolic rate, respiratory exchange ratio, body composition, fat mass, cardiometabolic health, young men, fasting blood glucose, insulin, lipids
- MeSH
- adipose tissue, humans, insulin, blood glucose, exercise, body composition, oxidation-reduction, oxygen consumption, adult, male, lipid metabolism, young adult, intermittent fasting
7 autores
- Hale Aktaş🇹🇷Hacettepe University
- Muhammed Mustafa ATAKAN🇹🇷Hacettepe University
- Selin Aktitiz🇹🇷Hacettepe University
- Zeynep Ergün🇹🇷Hacettepe University
- Şükran Nazan Koşar🇹🇷Hacettepe University
- Todd Anthony Astorino🇺🇸California State University, San Marcos
- Hüseyin Hüsrev Turnagöl🇹🇷Hacettepe University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Time-restricted eating (TRE) is a type of intermittent fasting, requiring individuals to limit their eating timeframe to specific hours in the day, while maintaining a fasting period greater than 12 h. Fat oxidation (FOx) is a critical determinant in the pathophysiology of metabolic diseases, with impaired FOx contributing to conditions such as insulin resistance and obesity, whereas enhanced FOx is associated with improved metabolic health. However, the impact of the 16:8 TRE model on FOx remains largely unexplored. The aim of this study was to determine the effect of a 6-week TRE on resting and exercise substrate oxidation, body composition, and blood markers related to metabolic health.
Methods
Thirty-three healthy, young males (age: 27.5 ± 6 years, body mass: 76.5 ± 8.4 kg, maximal oxygen uptake [V˙O2max]: 43.9 ± 6.6 mL·kg-1·min-1) were assigned to either TRE (n = 16) or control group (n = 17), with efforts to match baseline characteristics, including V˙O2max and body composition. The TRE group followed a 16:8 program for 6 weeks, while controls maintained their existing dietary habits. Body composition, blood glucose, insulin, blood lipids, resting substrate oxidation, and FOx during cycling at 40 % V˙O2max were assessed before and after the 6-week period. Data were analyzed using both intention-to-treat (ITT) and per-protocol approaches.
Results
Thirty-three participants were included in the ITT analysis, while 31 participants were included in the per-protocol analysis. Compared to baseline, results showed a significant difference (p -1·min-1versus Δ = -0.37 mg·kg FFM-1·min-1; p = 0.007), and carbohydrate oxidation (Δ = -0.39 mg·kg FFM-1·min-1versus Δ = 0.45 mg·kg FFM-1·min-1; p = 0.037) after the 6-week period. Exercise substrate oxidation and fasting blood glucose, insulin, triglycerides, total cholesterol, and high-density lipoprotein cholesterol did not significantly change over time in either group (p > 0.05).
Conclusions
In summary, a 6-week TRE significantly reduces body mass, fat mass, and resting RER as well as increases resting FOx in young, healthy males. However, it does not affect blood markers related to cardiometabolic health or exercise substrate oxidation. This trial was registered at https://clinicaltrials.gov/study/NCT06498102asNCT06498102.
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