A randomized controlled cross-over trial of differences in acute effects on serum metabolites from isocaloric meals based on red meat, fatty fish, or soy protein
Lindqvist HM, Hulander E, Bärebring L, Gjertsson I, Winkvist A
European journal of nutrition · 6 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Vetenskapsrådet
- Universidad u hospital
- Göteborgs Universitet
- Universidad u hospital
- University of Gothenburg
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-05-26 · Eur J Nutr · vol. 64 · número 5 · pág. 187
- Editorial
- Springer Science+Business Media
- Citado
- 5 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- Metabolite, Postprandial, Food science, Red meat, Soy protein, Meal, Plant protein, Chemistry, Fish meal, Biology, Biochemistry, Endocrinology, Fish <Actinopterygii>, Insulin
- MeSH
- animals, humans, arthritis, rheumatoid, methylamines, creatinine, dietary fats, dietary proteins, soybean proteins, diet, cross-over studies, postprandial period, adult, aged, middle aged, female, meals, red meat
5 autores
- Helen M. Lindqvist🇸🇪 · autor de correspondenciaUniversity of Gothenburg
- Erik Hulander🇸🇪University of Gothenburg
- Linnea Bärebring🇸🇪University of Gothenburg
- Inger Gjertsson🇸🇪Sahlgrenska University Hospital; University of Gothenburg
- Anna Winkvist🇸🇪University of Gothenburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Reducing red meat intake in the Western diet is beneficial for health and the environment. However, red meat is nutrient-rich, so understanding the impact of substituting it with other protein sources such as fish or plant-based proteins is essential, especially for vulnerable groups like the elderly and those with chronic diseases. The purpose of this study was to study the postprandial response in serum metabolites in women with Rheumatoid Arthritis (RA) after intake of red meat, fatty fish, and soy protein.
Methods
Women with RA (n = 24) consumed isocaloric meals that included burgers made from either red meat, fatty fish, or soy protein in a crossover design. Blood samples were taken in fasting state before the meal (0 h) and at intervals up to 5 h after eating. Nuclear Magnetic Resonance (NMR) analysis quantified serum metabolites, and multivariate models and univariate statistics were applied to compare postprandial metabolite changes across protein sources.
Results
Postprandial metabolite patterns varied significantly by protein type. The fatty fish meal led to a faster and higher increase in metabolites, including creatinine, isoleucine, valine, and trimethylamine N-oxide, compared to red meat. Unidentified lipids also differed. However, metabolite patterns after soy protein were similar to those after red meat.
Conclusion
This postprandial crossover trial found that intake of fatty fish lead to a quicker and more pronounced increase in key blood concentrations of metabolites compared to red meat. However, metabolite profiles in serum based on NMR-analysis were similar after intake of soy protein compared to red meat.
Trial registration
The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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