Rapid Reduction of Pro-Inflammatory Cytokines with an Oral Topical Composition Comprising Olive Oil, Trimethylglycine and Xylitol: A Randomized Double-Blind Controlled Trial
López-López J, Reuss JM, Vinuesa-Aumedes T, Egido-Moreno S, Roselló-Llabres X, Pereira-Riveros T, Reuss D, Alonso-Gamo L, Rodríguez-Vilaboa B
International journal of molecular sciences · 2 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-05-21 · Int J Mol Sci · vol. 26 · número 10 · pág. 4920
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 3 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Oral microbiology and periodontitis research · Adipokines, Inflammation, and Metabolic Diseases · Dental Health and Care Utilization
- Palabras clave
- olive oil, betaine, xylitol, toothpaste, salivary cytokines, IL-1β, TNF-α, IL-4, obesity, overweight, periodontitis, oral mucosa, anti-inflammatory activity, body mass index, chronic inflammation, periodontal health
- MeSH
- saliva, humans, obesity, xylitol, glycine, tumor necrosis factor-alpha, interleukin-4, cytokines, double-blind method, adult, middle aged, female, male, overweight, interleukin-1beta, olive oil
9 autores
- José López‐López🇪🇸Institut d'Investigació Biomédica de Bellvitge; Universitat de Barcelona
- José Manuel Reuss🇪🇸Universidad Complutense de Madrid
- Teresa Vinuesa🇪🇸Universitat de Barcelona
- Sonia Egido‐Moreno🇪🇸Universitat de Barcelona
- Xavier Roselló-Llabrés🇪🇸Universitat de Barcelona
- Tanya Pereira-Riveros🇪🇸Universitat de Barcelona
- Debora Reuss🇪🇸Universidad San Pablo CEU
- Laura Alonso-Gamo
- Beatriz Rodríguez-Vilaboa🇪🇸 · autor de correspondenciaUniversidad San Pablo CEU
Resumen
El texto original del estudio, en el idioma en que se publicó.
An underlying pro-inflammatory status is related to recurrence and persistence of inflammatory susceptibility in obesity and periodontitis, two of the most prevalent chronic inflammatory diseases. Elevated levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), part of the inflammatory network linking these two conditions, persist even after periodontal treatment, with high salivary cytokine levels being linked to overweight and obesity risk. This trial assessed the effect of a novel composition comprising olive oil, trimethylglycine and xylitol, delivered topically to the oral mucosa, on salivary cytokines in periodontally healthy normal and overweight/pre-obese individuals. In a randomized placebo-controlled double-blind clinical trial, adult patients were randomly assigned to use a test toothpaste (intervention group, IG) or a placebo toothpaste (control group, CG) three times a day for 1 month. Primary outcomes were levels of salivary cytokines IL-1β, TNF-α and interleukin-4 (IL-4). Significant differences between IG and CG were observed for IL-1β (p = 0.003; Z = 2.901; r = 0.62) and TNF-α (p = 0.001; Z = 3.23; r = 0.69), but not for IL-4 (p = 0.203; Z = 1.321; r = 0.28). A significant reduction in IL-1β (p = 0.008) and a near significant reduction in TNF-α (p = 0.059) was found in the IG at the end of the trial. Additionally, the effect of body mass index on cytokine levels response was analyzed. A significantly different behavior was shown between IG and CG in the overweight/pre-obesity subgroup for IL-1β (p = 0.014; Z = 2.430; r = 0.63) and TNF-α (p = 0.029; Z = 2.199; r = 0.57). Moreover, a significant decrease in IL-1β in the IG (p = 0.028) was observed. The rapid reduction in IL-1β and TNF-α after 1 month of use of the intervention composition suggests a safe and effective novel strategy for reducing pro-inflammatory cytokines that may offer an opportunity to diminish the inflammatory status in patients with overweight/pre-obesity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.