Olive oil consumption and risk of breast cancer: Prospective results from the Moli-sani Study, and a systematic review of observational studies and randomized clinical trials
Ruggiero E, Sharma S, Di Castelnuovo A, Costanzo S, Panzera T, Esposito S, Cerletti C, Donati MB, de Gaetano G, Iacoviello L, Bonaccio M, Moli-sani Study Investigators
European journal of cancer (Oxford, England : 1990) · 3 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministero della Salute
- Gobierno
- Ministero dello Sviluppo Economico
- Gobierno
- Ministero delle imprese e del made in Italy
- Subvenciones
- Ministero della Salute (2025\u20132027); Ministero dello Sviluppo Economico (2924 del 12/10/2022); Ministero dello Sviluppo Economico (F/200115/01-02/X45)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2025-05-24 · Eur J Cancer · vol. 224 · pág. 115520
- Editorial
- Elsevier BV
- Citado
- 5 citas · más que el 78% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 68 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Edible Oils Quality and Analysis · Cancer Risks and Factors
- Palabras clave
- olive oil consumption, breast cancer risk, monounsaturated fatty acids, polyphenols, estrogen receptor-positive breast cancer, progesterone receptor-positive breast cancer, HER2-negative breast cancer, hormone receptor-negative breast cancer, Moli-sani Study, dietary fat intake, breast cancer prevention, women's health, Italy, Mediterranean diet
- MeSH
- humans, breast neoplasms, risk factors, prospective studies, adult, aged, middle aged, italy, female, randomized controlled trials as topic, olive oil, observational studies as topic
11 autores
- Emilia Ruggiero🇮🇹Istituto Neurologico Mediterraneo
- Sukshma Sharma🇮🇹Istituto Neurologico Mediterraneo
- Augusto Filippo Di Castelnuovo🇮🇹Istituto Neurologico Mediterraneo
- Simona Costanzo🇮🇹University of Insubria; Istituto Neurologico Mediterraneo
- Teresa Panzera🇮🇹Istituto Neurologico Mediterraneo
- Simona Esposito🇮🇹Istituto Neurologico Mediterraneo
- Chiara Cerletti🇮🇹Istituto Neurologico Mediterraneo
- Maria Benedetta Donati🇮🇹Istituto Neurologico Mediterraneo
- Giovanni de Gaetano🇮🇹Istituto Neurologico Mediterraneo
- Licia Iacoviello🇮🇹 · autor de correspondenciaIstituto Neurologico Mediterraneo
- Marialaura Bonaccio🇮🇹Istituto Neurologico Mediterraneo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Breast cancer (BC) is the leading cause of cancer-related death among women worldwide. Olive oil, rich in monounsaturated fats and polyphenols, has been linked to a reduced BC risk, but epidemiological evidence remains limited. This study examined the association between olive oil consumption and BC risk in a large cohort of adult Italian women and conducted a systematic review on this association.
Methods
Longitudinal analyses were performed on 11,442 women (mean age 54.7 ± 11.6 years) enrolled in the Moli-sani Study (2005-2010). Cox proportional hazard models were used to estimate BC risk in relation to olive oil consumption. A systematic review was conducted by searching Scopus, EMBASE, PubMed, and MEDLINE databases up to October 2024 for observational studies and RCTs.
Results
Compared with lower olive oil consumption (≤2 tbsp./day), multivariable-adjusted HRs associated with highest intake (>3 tbsp./d) for overall, premenopausal, and postmenopausal BC were 0.71(95 %CI 0.48-1.05), 0.80 (95 %CI 0.28-2.28), and 0.70 (95 %CI 0.46-1.08), respectively. An increase of 1-tbsp./d of olive oil was associated with a lower risk of ER and PR breast cancers (HR=0.32; 95 %CI 0.13-0.77), particularly ER cases (HR=0.32; 95 %CI 0.15-0.69); additionally, a lowered hazard of HER2- BC incidence was observed at highest consumption of olive oil compared to the bottom category (HR=0.54; 95 %CI 0.31-0.96). The systematic review included 13 observational studies (11 case-control and 2 prospective) and 1 RCT. While case-control studies and the RCT suggested a protective effect associated with olive oil consumption, longitudinal studies reported no association.
Conclusions
Findings from the Moli-sani Study suggest an inverse association between olive oil consumption and the risk of hormone receptor-negative breast cancers, particularly ER subtype, while results were inconclusive for overall BC risk. The systematic review revealed that case-control studies more frequently reported a protective association, whereas prospective studies did not consistently support this finding.
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