Effects on choroid after repeated low-level red-light therapy in preclinical and clinical myopic children: a randomized controlled trial
Wei H, Thakur S, Zhu Q, Zhou Y, Cao X, Xiao S, Chen Q, Hu M, Zhong H
Photodiagnosis and photodynamic therapy · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Kunming Medical University
- Gobierno
- Yunnan Provincial Science and Technology Department
- Gobierno
- National Natural Science Foundation of China-Yunnan Joint Fund
- Subvenciones
- Yunnan Provincial Science and Technology Department (202001AY070001-210); Yunnan Provincial Science and Technology Department (202301AY070001-002); Kunming Medical University (2024XKTDTS01); National Natural Science Foundation of China-Yunnan Joint Fund (82360212)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2025-05-29 · Photodiagnosis Photodyn Ther · vol. 54 · pág. 104651
- Editorial
- Elsevier BV
- Citado
- 9 citas · más que el 97% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Retinopathy of Prematurity Studies
- Palabras clave
- Randomized controlled trial, Medicine, Light therapy, Internal medicine
- MeSH
- choroid, humans, myopia, tomography, optical coherence, photochemotherapy, prospective studies, child, female, male
9 autores
- Hongyu Wei🇨🇳Kunming Medical University; First Affiliated Hospital of Kunming Medical University
- Sahil Thakur🇸🇬Singapore Eye Research Institute
- Qin Zhu🇨🇳Yunnan University; Second People's Hospital of Yunnan Province
- Yanrong Zhou🇨🇳Yunnan University; Second People's Hospital of Yunnan Province
- Xuejun Cao🇨🇳Kunming Medical University; First Affiliated Hospital of Kunming Medical University
- Shu‐Yuan Xiao🇨🇳Kunming Medical University; First Affiliated Hospital of Kunming Medical University
- Qin Chen🇨🇳Nanjing Medical University
- Min Hu🇨🇳Yunnan University; Second People's Hospital of Yunnan Province
- Hua Zhong🇨🇳 · autor de correspondenciaKunming Medical University; First Affiliated Hospital of Kunming Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To evaluate how choroidal thickness (CT) and choriocapillaris flow deficit density (CCD) change within 6000 µm of the macula following repeated low-level red-light (RLRL) therapy, and to assess whether early choroidal alterations can predict long-term myopia control.
Methods
This is a secondary analysis of a prospective randomized controlled trial. Two hundred children with spherical equivalent refraction (SER) of -6.00D to +0.50D were randomized to receive either twice-daily RLRL therapy or no additional intervention (control). Axial length (AL), cycloplegic SER, CT, and CCD were measured at the baseline and at 1, 3, 6 and 12 months.
Results
Baseline characteristics were similar between groups. In the RLRL group, subfoveal choroidal thickness (SFCT) increased progressively over time, reaching its maximum at 12 months; by contrast, SFCT declined in controls. Within the 6000 µm macular zone, CT rose in the RLRL group but fell uniformly in the control group. Improvements on choriocapillaris blood flow were evident at 3 months post-RLRL, yet these changes were not sustained and did not correlate with longer-term choroidal thickening. A prediction model using only the "6-month SFCT change" demonstrated comparable accuracy for forecasting satisfactory myopia control at 12 months to more complex multivariable models.
Conclusions
RLRL therapy induces a marked and sustained thickening of the macular choroid within 6000 µm, while its effects on choriocapillaris perfusion are transient. Moreover, the magnitude of SFCT increase at 6 months alone provides a reliable early predictor of 12-month myopia control efficacy. Trial Registration This trial was registered at the Chinese Clinical Trial Registry on January 30, 2021, with trial registration number: ChiCTR2100042836. https://www.chictr.org.cn/showprojEN.html?proj=120971.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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