The impact of intermittent fasting and Mediterranean diet on older adults' physical health and quality of life: A randomized clinical trial
Couto S, Cenit MC, Montero J, Iguacel I
Nutrition, metabolism, and cardiovascular diseases : NMCD · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-05-16 · Nutr Metab Cardiovasc Dis · vol. 35 · número 10 · pág. 104132
- Editorial
- Elsevier BV
- Citado
- 8 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Palabras clave
- intermittent fasting, time-restricted eating, Mediterranean diet, older adults, quality of life, anthropometric measures, waist circumference, waist-to-hip ratio, systolic blood pressure, fasting blood glucose, gamma-glutamyl transferase, dietary adherence, meal timing
- MeSH
- humans, blood glucose, treatment outcome, fasting, age factors, health status, diet, mediterranean, blood pressure, time factors, quality of life, aged, middle aged, female, male, waist circumference, biomarkers, diet, healthy, intermittent fasting
4 autores
- Sergio Couto🇪🇸Universidad de Zaragoza
- María Carmen Cénit🇪🇸Consejo Superior de Investigaciones Científicas; Estación Experimental del Zaidín
- Jesica Montero🇪🇸Hospital Clínico Universitario Lozano Blesa
- Isabel Iguacel🇪🇸 · autor de correspondenciaUniversidad de Zaragoza; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto de Investigación Sanitaria Aragón
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Non-communicable chronic diseases are on the rise globally, and diet plays a crucial role. Intermittent fasting (IF), particularly time-restricted eating (TRE), has emerged as a potential strategy to manage these conditions. Research suggests that TRE, combined with healthy diets like the Mediterranean diet, may benefit populations, including older adults.
Methods and results
Seventeen adults over 60 years of age were randomly assigned to the TRE + MED group (n = 8), following a 12-h fast with the Mediterranean diet, or the MED-DIET group (n = 9), following the diet without fasting. Over three months, changes in anthropometric, biochemical, and quality of life measures were assessed. The TRE + MED group showed significant reductions in BMI (p = 0.040), waist circumference (p < 0.001), hip circumference (p = 0.025), waist-to-hip ratio (p = 0.023), and systolic blood pressure (SBP) (p = 0.020), along with changes in fasting glucose. In the MED-DIET group, only SBP decreased significantly (p = 0.022). Between-group comparisons showed greater improvements in waist circumference (p = 0.001) and waist-to-hip ratio (WHR; p = 0.036) in the TRE + MED group. Conversely, gamma-glutamyl transferase (GGT) levels improved more in the MED-DIET group (p = 0.020). However, in the between-group comparison, only the reduction in waist circumference, WHR, and GGT levels reached statistical significance. Both groups improved Mediterranean diet adherence, quality of life, and stool regularity, but only 20 % of the TRE + MED group was willing to continue fasting, compared to 100 % in the MED-DIET group.
Conclusion
TRE combined with the Mediterranean diet offers superior health benefits compared to the Mediterranean diet alone. In addition, adhering to a consistent meal schedule and regulating meal timing appear to be more challenging for the studied population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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