Ultra-Processed Food Intake and Risk of Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis of Prospective Studies
Kim Y, Cho Y, Kim JE, Lee DH, Oh H
Diabetes & metabolism journal · 9 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation
- Universidad u hospital
- Korea University
- Gobierno
- National Research Foundation of Korea
- Subvenciones
- National Research Foundation of Korea (RS-2025-00563263); Korea University (K2402691); National Research Foundation of Korea (2023S1A5C2A03095169)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-06-09 · Diabetes Metab J · vol. 49 · número 5 · págs. 1064–1074
- Editorial
- Korean Diabetes Association
- Citado
- 15 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- ultra-processed foods, type 2 diabetes, dose-response relationship, processed meat, threshold effects, diet quality, energy intake, body mass index
- MeSH
- humans, diabetes mellitus, type 2, body mass index, diet, risk factors, prospective studies, energy intake, fast foods, food, processed
5 autores
- Yujin Kim🇰🇷Korea University
- Yoonkyoung Cho🇰🇷🇺🇸Korea University; University of Michigan
- Jin Eui Kim🇰🇷Korea University
- Dong Hoon Lee🇺🇸🇰🇷Harvard University; Yonsei University
- Hannah Oh🇰🇷 · autor de correspondenciaKorea University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Backgruound
Although some studies suggest a positive association between ultra-processed food (UPF) intake and type 2 diabetes mellitus (T2DM), little is known about the exact shape and risks associated with different units (percentage of g/day, absolute g/day, serving/day) of UPF intake and whether the association is independent of diet quality, total energy intake, and body mass index (BMI).
Methods
Prospective studies published through January 2024 were identified by searching PubMed, Embase, and Web of Science. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated using random-effects models. A nonlinear dose-response meta-analysis was conducted using restricted cubic spline analysis.
Results
After screening 569 publications, a total of 12 prospective cohort studies were included. Comparing the highest vs. lowest categories of intake, summary RR for T2DM risk was 1.48 (95% CI, 1.36 to 1.61). Higher summary RRs were observed among studies from Europe and North America. Among individual UPF subgroups, processed meats (summary RR, 1.34; 95% CI, 1.16 to 1.54) were positively associated, whereas ultra-processed cereals and breads (0.98; 95% CI, 0.97 to 0.99) and packaged savory snacks (0.92; 95% CI, 0.88 to 0.95) were inversely associated. The summary RRs associated with every 10% (of g/day), 100-g/day, and 1-serving/day increase in UPF intake were 1.14 (95% CI, 1.11 to 1.17), 1.05 (95% CI, 1.03 to 1.06), and 1.04 (95% CI, 1.03 to 1.05), respectively. The dose-response curve for absolute g/d intake suggested nonlinearity, showing a steeper risk increase approximately at >300 g/day. The associations persisted after adjustment for diet quality, energy intake, or BMI.
Conclusion
Our data suggest that UPF intake increases diabetes risk, with a potential threshold effect at 300 g/day.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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