Financiado en parte por Taisho Toyama Pharmaceutical Company, Taisho Pharmaceutical Co., Ltd., Taisho Pharmaceutical (Japan)
The Effects of Creatine Monohydrate Supplementation on Recovery from Eccentric Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial Considering Sex and Age Differences
Yamaguchi S, Inami T, Nishioka T, Morito A, Ishiyama K, Murayama M
Nutrients · 3 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Keio University
- Empresa
- Taisho Toyama Pharmaceutical Company
- Empresa
- Taisho Pharmaceutical Co., Ltd.
- Empresa
- Taisho Pharmaceutical (Japan)
- Subvenciones
- Taisho Toyama Pharmaceutical Company (H11PA22111)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-05-23 · Nutrients · vol. 17 · número 11 · pág. 1772
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 94% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Muscle metabolism and nutrition · Sports Performance and Training
- Palabras clave
- Delayed onset muscle soreness, Medicine, Placebo, Eccentric, Creatine, Creatine Monohydrate, myalgia, Randomized controlled trial, Physical therapy, Population, Muscle damage, Placebo-controlled study, Eccentric exercise, Muscle fatigue, Internal medicine, Physical medicine and rehabilitation, Double blind, Electromyography
- MeSH
- muscle, skeletal, humans, creatine, exercise, double-blind method, age factors, sex factors, recovery of function, muscle fatigue, muscle contraction, dietary supplements, adult, female, male, young adult, myalgia
6 autores
- Shota Yamaguchi🇯🇵Keio University
- Takayuki Inami🇯🇵 · autor de correspondenciaKeio University
- Takuya Nishioka🇯🇵Keio University
- Akihisa Morito🇯🇵Taisho Pharmaceutical (Japan)
- Kaho Ishiyama🇯🇵Taisho Pharmaceutical (Japan)
- Mitsuyoshi Murayama🇯🇵Keio University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: In this study, we aimed to examine the effect of creatine monohydrate (CrM) supplementation on recovery from eccentric exercise-induced muscle damage (EIMD) in diverse populations, including different sexes and age groups. EIMD decreases maximal voluntary contraction (MVC), restricts the range of motion (ROM), and increases muscle stiffness and delayed-onset muscle soreness, all of which negatively impact athletic performance. Therefore, developing effective recovery strategies is essential. Methods: A double-blind, randomized, placebo-controlled trial was conducted with 40 healthy male and female participants. After 33 days of supplementation with either CrM or placebo (crystalline cellulose), the participants performed eccentric exercises. Recovery indices, including MVC, muscle stiffness, subjective muscle extensive soreness, fatigue, and upper arm circumference, were measured at baseline, immediately after exercise, 48 h post-exercise, and 96 h post-exercise. Results: The creatine supplementation group (CRE) demonstrated a significantly quicker recovery of MVC than the placebo group (PLA). Furthermore, reductions in shear modulus and muscle fatigue were observed in the CRE group. Notably, females in the CRE group exhibited a significant suppression of post-exercise edema, suggesting a sex-specific response. Conclusions: These findings indicate that CrM supplementation may enhance recovery from EIMD, contributing to the maintenance of muscle function and the reduction of discomfort after exercise. CrM has the potential to serve as a practical nutritional strategy to promote recovery, not only for athletes, but also for a broader population.
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